Hip Disease, Hip Fractures
Conditions
Brief summary
In this study, mononuclear cells, particularly monocytes, were collected from the peripheral blood of elderly patients who underwent orthopedic hip surgery under spinal anesthesia. We then observe the accumulation of chloride intracellular channel 1 (CLIC1), particularly the characteristic accumulation morphology and its function. The purpose of this study is to compare whether there is a difference in the degree and form of cytoplasmic CLIC1 accumulation between the elderly group with postoperative delirium (PD) and the elderly group without postoperative delirium. We'll also confirm whether this is appropriate as a predictor of postoperative delirium. In addition, we will establish a control group for the non-elderly group to check the difference due to aging itself.
Interventions
BEHAVIORALPerioperative delirium
Perioperative delirium
PROCEDUREHip surgery
Orthopedic hip joint surgery under spinal anesthesia
Sponsors
Seoul National University Bundang Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Male or female patients aged 65 years or older who are scheduled to undergo surgery for an orthopedic hip fracture under spinal anesthesia
Exclusion criteria
* Patients who are unconscious * Patients who are unable to communicate * Alzheimer * Parkinson Disease * Conversion to general anesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| expression pattern of CLIC1 protein | Immediate after spinal anesthesia |
Countries
South Korea
Outcome results
None listed