Alzheimer Disease, Dementia, Vascular
Conditions
Keywords
Positron-Emission Tomography, Perfusion
Brief summary
Alzheimers disease and cerebral small vessel disease have a considerably overlap in patients and have common risk factors. The diseases are difficult to separate in individual patients and we hypothesize that a reduced cerebral vascular reserve may be a measurement of small vessel disease independent of Alzheimers disease. Patients with presumed Alzheimers disease (n=20), cerebral small vessel disease (n=20) and healthy age-matched subjects (n=15) are examined with quantitative \[15O\]H2O positron emission tomography (PET) for measurements of brain perfusion before and after diamox infusion that dilates cerebral vessels. Additional \[15O\]H2O PET scans of the heart allows for a non-invasive input function so the cerebral vascular reserve can be measured quantitatively.
Detailed description
Alzheimers disease and cerebral small vessel disease are increasingly common in the elderly population and constitute around 90% of new dementia cases in Denmark. The diseases have a considerably overlap in patients and have common risk factors. The cause of dementia can be difficult to separate in individual patients but a reduced cerebral vascular reserve may be a measurement of small vessel disease independent of Alzheimers disease. We hypothesized that patient with small vessel disease have reduced increase in brain perfusion after medical brain vessel dilatation. While Alzheimer patients may have reduced perfusion in rest but normal increase after medical brain vessel dilatation as compared to healthy subjects. Patients with presumed Alzheimers disease (n=20), cerebral small vessel disease (n=20) and healthy age-matched subjects (n=15) are examined with quantitative \[15O\]H2O PET for measurements of brain perfusion before and after diamox infusion that dilates cerebral vessels. Additional \[15O\]H2O PET scans of the heart allows for a non-invasive input function so the cerebral vascular reserve can be measured quantitatively.
Interventions
DIAGNOSTIC_TESTCerebral [15O]H2O PET before and after diamox infusion
Cerebral \[15O\]H2O PET before and after diamox infusion
Sponsors
Bispebjerg Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* presumed Alzheimer's Disease (group 1) * diagnosed with small vessel disease of the brain by MRI and presumed cognitive dysfunction (group 2)
Exclusion criteria
* major claustrophobia * major psychiatric diseases * other major somatic diseases * allergy to diamox
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular reserve perfusion | 20 min after diamox infusion | Brain perfusion after diamox infusion (mL / min / 100 g tissue) |
| Vascular reserve change | 20 min after diamox infusion | Change in Brain perfusion after diamox infusion (mL / min / 100 g tissue and %) compared to before diamox infusion |
Countries
Denmark
Contacts
Primary ContactLisbeth Marner, MD, PhD
Outcome results
None listed