Unicompartmental Knee Arthroplasty vs. High Tibial Osteotomy for Medial Knee Osteoarthritis (UNIKORN): a Study Protocol of a Randomized Controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05442242

Acronym

UNIKORN

Enrollment

100

Registered

2022-07-01

Start date

2022-11-30

Completion date

2025-12-31

Last updated

2022-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Brief summary

Unicompartmental knee arthroplasty (UKA) and High Tibial Osteotomy are both valid treatment options for isolated medial knee osteoarthritis. Literature to date is lacking high grade evidence of the outcomes between these procedures. This is a study protocol for randomized controlled trial comparing UKA vs HTO in late stage medial knee osteoarthritis.

Interventions

PROCEDUREUnicompartmental knee arthroplasty

Medial Unicompartmental knee arthroplasty

PROCEDUREHigh tibial osteotomy

Medial open wedge high tibial osteotomy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

45 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Isolated KL 3-4 medial knee arthrosis * Varus \> 3 degrees * Age 45-65 years

Exclusion criteria

* Post-traumatic arthrosis * Arthrosis in the lateral compartment more than KL grade I in MRI * Post- traumatic arthrosis * Instability * Malignancy Obesity

Design outcomes

Primary

Measure	Time frame
KOOS	1- year

Contacts

Primary ContactJuuso Siren, MD

juuso.siren@hus.fi0407005858

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 9, 2026