Cardiac Output, High, Hypercapnia, Hypoxia
Conditions
Keywords
Cardiac Output, Perfusion index, Pulse oximetry
Brief summary
The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.
Detailed description
Hypercapnia causes changes in physiological parameters at various levels throughout the body. The study aims to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia. It is an intervention prospective study that will be conducted at the Faculty of Biomedical Engineering on healthy volunteers. All the volunteers undergo three different phases in random order. The individual phases differ in the breathed mixture of oxygen, nitrogen and carbon dioxide gases. Non-invasive measurements of physiological parameters, especially blood oxygen saturation, perfusion index and cardiac output, will be performed continuously during the experiment.
Interventions
OTHERHypoxic
Hypoxic gas mixture Gas mixture of 10% O2 and 90% N2 for six minutes.
OTHERHypercapnic
Hypercapnic gas mixture Gas mixture of 21% O2, 5% CO2 74% N2 for six minutes.
OTHERHypoxic and Hypercapnic
Hypoxic and Hypercapnic gas mixture Gas mixture of 10% O2, 5% CO2 85% N2 for six minutes.
Sponsors
Czech Technical University in Prague
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)
Masking description
The participant undergoes all three phases of the experiment and the participant does not know which one is it.
Intervention model description
Interventional single blinded randomized crossover prospective study. All participants go through all study arms, in random order.
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers
Exclusion criteria
* pregnancy * severe cardiovascular conditions * severe asthma or other severe respiratory conditions * injury to the upper limbs or hands that could affect the peripheral perfusion * diabetes * hypotension or hypertension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Cardiac output due to the induced hypoxia and hypercapnia | 1 hour | Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Cardiac output will change |
| Changes in Perfusion index due to the induced hypoxia and hypercapnia | 1 hour | Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Perfusion index will change |
Countries
Czechia
Contacts
PRINCIPAL_INVESTIGATORKarel Roubik, Professor
Czech Technical University in Prague
Outcome results
None listed