Colorectal Neoplasms
Conditions
Brief summary
A large-scale randomized controlled trial was conducted to compare different colorectal neoplasms screening strategies.
Interventions
DIAGNOSTIC_TESTFecal immunochemical test
Fecal immunochemical test can concentrate the high-risk population.
DIAGNOSTIC_TESTAPCS score
APCS score can concentrate the high-risk population.
Sponsors
Shandong University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 74 Years
Healthy volunteers
No
Inclusion criteria
* 50-74 years old * Informed consent is available
Exclusion criteria
* Previous colorectal cancer * Previous colorectal resection * Previous received cancer-related treatment (except non-melanoma skin cancer) * Colonoscopy, sigmoidoscopy, CT colonoscopy, and barium enema were performed within 5 years * Fecal occult blood or fecal DNA was performed within one year * Symptoms of lower digestive tract diseases requiring colonoscopy include: (1) rectal bleeding occurred more than once in the past 6 months, (2) recorded iron deficiency anemia, and (3) recorded significant weight loss within 6 months (\> 10% of baseline weight) * Suffering from other diseases that affect the benefit of screening or intolerance to colonoscopy (for example, severe pulmonary disease, end-stage renal disease, end-stage liver disease, severe heart failure or recently diagnosed cancer, except non-melanoma skin cancer)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection rate | up to 30 months | Detection of intestinal lesions in population |
Outcome results
None listed