Elasticity Imaging Techniques, Knee Osteoarthritis
Conditions
Brief summary
Knee osteoarthritis (OA) is a common problem in clinical settings. Knee OA is well known for its association with the wear and tear of the cartilage and osteophyte formation. Evidence has suggested the importance of the infrapatellar fat pad, known as Hoffa's fat pad, during the development of knee OA. Some studies have demonstrated the protective role of the infrapatellar fat pad, whereas others have suggested an inflammatory role such as increased fibrosis and proinflammatory cytokine levels. Ultrasound is exceptionally convenient in the assessment of the musculoskeletal system, and elastography is a tool to evaluate tissue texture. Therefore, in this study, we investigated the Hoffa's fat pad in knee OA patients by using elastography.
Detailed description
This was an observation study that included a control group. We enrolled 20 patients with knee OA, as well as 10 healthy individuals. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren-Lawrence X-ray grading were employed to determine disease severity. All the study participants received elastography assessment, including strain and shear wave elastography in the knee extension and flexion position. The strain elastography contained color mapping that enabled the calculation of the relative texture and strain ratio. The shear wave elastography revealed the qualitative velocity, which was measured 3 times. Each patients with knee OA received elastography examination twice: once before hyaluronic acid injection and once 1 month after the injection.
Interventions
None listed
Sponsors
Taipei Veterans General Hospital, Taiwan
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 86 Years
Healthy volunteers
Yes
Inclusion criteria
OA group * Kellgren-Lawrence grading I-IV proved by knee X-ray Healthy group * No knee pain or received injection during the past 1 year * No history of knee OA
Exclusion criteria
* History of knee surgery, trauma or malignancy * History of patellar tendinopathy or patellofemoral pain syndrome * Refused informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| shear modulus | before and 1-3 months after hyaluronic acid injection | the absolute quantitative measurement of elasticity (kPa) of Hoffa's fat pad |
| strain ratio | before and 1-3 months after hyaluronic acid injection | the semiquantitative measurement of elasticity of Hoffa's fat pad, a ratio with patellar tendon as reference |
| thickness of Hoffa's fat pad | before and 1-3 months after hyaluronic acid injection | the thickness of Hoffa's fat pad from mid patellar tendon to femur cartilage |
Countries
Taiwan
Outcome results
None listed