Depression, Depression and Suicide, Depression in Adolescence, Depression, Teen, Major Depressive Disorder, MDD, Suicidal Ideas, Suicide, Suicide, Attempted
Conditions
Brief summary
This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This research is also to test the effects of standard treatment of depression on improvement in depressive and suicidal behavior and on biomarkers (e.g. miRNA) for these disorders.
Interventions
GENETICGenetic testing
Attempting to identify the genetic biomarker that can identify risk for suicidal ideation and action
Sponsors
University of Alabama at Birmingham
National Institute of Mental Health (NIMH)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
10 Years to 24 Years
Healthy volunteers
Yes
Inclusion criteria
All participants: 1. Physically healthy 2. willing and able to provide informed consent (if under 18 also parent or guardian consent) MDD participants: 1. A definite diagnosis of DSM-5 2. a Children's Depression Rating Scale-Revised (CDRS-R) score \>=30. Suicidal ideation participants: Columbia Suicide Severity Rating Scale (C-SSRS) score \>=4 rated over the last two weeks. Suicide attempt group: 1\. Participants will have had an attempt in the previous two weeks that is serious enough to require medical attention and shows evidence of at least a medium level of intent on the Suicide Intent Scale. Non-psychiatric controls: 1\. No history of any major mental illness (excluding specific phobia) or substance use disorder.
Exclusion criteria
*
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical phenotype analysis | 6 Weeks |
Countries
United States
Contacts
CONTACTAllison Stewart, MA
Outcome results
None listed