Atrial Fibrillation
Conditions
Brief summary
Using state of the art cardiac magnetic resonance imaging techniques, characterization of ablation lesions in the early phase after pulmonary vein isolation ablation in atrial fibrillation patients, and relate findings to the ablation scar at 3 months follow up and atrial fibrillation-free survival at 1 year.
Interventions
PROCEDUREMRI
MRI prior to PVI, acutely after PVI, and 3 months after PVI
Sponsors
Amsterdam UMC, location VUmc
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients (age ≥18 years old) * Paroxysmal or persistent AF meeting guideline criteria. * Anticipated PVI using index-guided radiofrequency ablation techniques. * Availability of LGE-CMR images within 3 months before anticipated PVI.
Exclusion criteria
* History of catheter ablation * History of cardiac surgery. * History of chest radiation therapy * Estimated glomerular filtration rate (eGFR) \<45 ml/min/kg * Known (or suspected) allergic reaction to gadolinium * Contraindications for CMR (such as claustrophobia, certain implants, devices, high body mass index). * Inability to schedule CMR \<48h after PVI * Long-term use of anti-inflammatory medication, except for the use of nonsteroidal anti-inflammatory drugs * Autoimmune disease or chronic inflammatory illness. * Pregnancy of breast feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ablaton scar | 3 months | The correlation between ablation lesion characteristics in the early phase after PVI and ablation scar at 3 months follow up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| AF recurrence | 1 year | The relation between ablation lesion characteristics and AF recurrence at 1 year after the ablation procedure |
Outcome results
None listed