Chronic Obstructive Pulmonary Disease
Conditions
Brief summary
COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations. a second collection for the year +1 will be made, at the same time (between October and March).
Detailed description
The subjects will be recruited during a medical visit in the Departments of Pneumology and Occupational and Environmental Pathologies. After information and inclusion of the subject in the study, a collection of clinical data, the state of health and the smoking status of the subject will be carried out by the clinical study technician. A collection of the exhalation will also be carried out by the clinical study technician. Several groups of subjects will be formed according to pathologies (COPD versus non-COPD), age and smoking status
Interventions
OTHERcollection of human exhalation
the collection of the exhalation will be carried out with a non-invasive device manufactured by a Chinese company. The collection of exhalation consists of the subject inhaling through the nose and exhaling gently through the mouth through a plastic straw for a time set at 5 min in the device
Sponsors
Centre Hospitalier Intercommunal Creteil
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
For COPD: * Patients with chronic obstructive pulmonary disease * Age: over 18 For non-COPD * Absence of chronic obstructive pulmonary disease * Age: between 18 and 30 years old and between 45 and 70 years old
Exclusion criteria
* Taking certain medications in the month preceding the sample (antibiotics, systemic corticosteroids, immunosuppressants) * Person under guardianship or curatorship * Pregnant or breastfeeding women * Person unable to express his/her opposition, person deprived of liberty * Existence of a chronic infectious pulmonary pathology such as (dilation of the bronchi, cystic fibrosis)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number and dominant bacterial species in human exhalations of COPD subjects and non-COPD subjects | Baseline | number and bacterial species |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number and dominant bacterial species in human exhalations according to smoking status | Baseline | number and bacterial species |
| Number and dominant bacterial species in human exhalations according to age | Baseline | number and bacterial species |
| Number and dominant bacterial species in human exhalations for patients returning for consultation 1 year apart during the winter season | 1 year | number and bacterial species |
Countries
France
Contacts
CONTACTJean-Claude PAIRON, PhD
CONTACTCamille JUNG, PhD
PRINCIPAL_INVESTIGATORJean Claude PAIRON, PhD
CHI créteil
Outcome results
None listed