Breast Cancer, Breast Cancer Female, DCIS, Stage I Breast Cancer, Stage II Breast Cancer
Conditions
Brief summary
The standard treatment for breast cancer when cancer cells were found near or within the margins of the tissue that is removed during breast surgery, is radiation of the entire chest wall. This may be considered overtreatment since the only reason for doing so is that cancer cells were near or in the margins of the breast tissue that was removed. In this study, the amount of radiation treatment will be limited to the area where the remaining cancer cells were found after surgery. The purpose of this study is to find out if partial chest wall radiation therapy is as good as whole chest wall radiation therapy in reducing the risk of breast cancer cancer coming back.
Interventions
RADIATIONPartial Chest Wall Radiation Therapy
Patients will receive radiation therapy (30 Gray in 5 fractions) to the affected chest wall, delivered on consecutive days or every other day
Sponsors
Stony Brook University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* DCIS or stage T1 or T2 invasive breast cancer, lymph node negative * Must have undergone mastectomy * Presence of cancer cells on or close to surgical margins * Negative pregnancy test for women * Must receive radiation at Stony Brook University Hospital
Exclusion criteria
\- Received prior radiation to are to be irradiated
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Breast cancer recurrence | 5 years | Number of patients with recurrent breast cancer |
| Acute toxicity | 3 months | Frequency of radiation-related adverse events |
| Delayed toxicity | 5 years | Frequency of radiation-related adverse events |
| Surgical complications | 5 years | Number of patients with surgical complications |
Countries
United States
Outcome results
None listed