Echocardiography
Conditions
Brief summary
There is high incidence of hypertensive disorders during pregnancy.The maternal cardiovascular system had significant changes during pregnancy. The colloid oncotic pressure is decreased during preeclampsia.
Detailed description
Transthoracic echocardiography considered an accurate non-invasive device and has validity for measuring cardiac functions in pregnancy.
Interventions
DRUG1000 mL of ringer's acetate solution
1000 mL of ringer's acetate solution
DRUG250 mL 6% hydroxyethyl starch (Voluven) then 500 mL of ringer's acetate solution then 250 mL of 6% hydroxyethyl starch (Voluven)
500 mL 6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride plus 500 mL of ringer's acetate solution
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
All the fluids were prepared according to the group by an anesthetist who will not be involved in data collection. All the bottles were wrapped by opaque cover.
Intervention model description
Patients will be randomly allocated via sealed opaque envelops into 2 groups of 17 patients each; crystalloid group and group crystalloid-colloid group
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Pre-eclampsia * Age 18-45 years. * Singleton pregnancy scheduled for elective CS delivery under spinal anesthesia. * American Society of Anesthesiologists (ASA Ⅱ, Ⅲ).
Exclusion criteria
* Body mass index \< 18 or ≥40 kg/m² * Women presenting in labor * Current administration of vasoactive drugs including salbutamol and thyroxin. * Diabetes mellitus. * Hemoglobin \<10 g/dl. * Cardiovascular, cerebrovascular, or renal disease * Increased serum creatinine level ≥1.1 mg/dL. * Contraindications to spinal anesthesia:(increased intracranial pressure, coagulopathy, or local skin infection)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac output measurement | 1 hour from the spinal anesthesia | 1 hour post spinal anesthesia after administration of 1000 mL fluid using Transthoracic Echocardiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Left ventricular end diastolic volume (LVEDV) measurement | 1 hour from the spinal anesthesia | milliliter |
| Urine output volume | 1hour and 2 hours post spinal anesthesia | milliliters |
| Cardiac output measurement | 5 minutes after the spinal anesthesia, after delivery of the fetus and 2 hours post spinal anesthesia | at baseline ,5 minutes after spinal anesthesia, after delivery of the fetus and 2 hours post spinal anesthesia |
| Heart rate (HR) | basal (preoperative), intraoperative each 10 minutes and postoperatively every hour during first 6 hours | beats per minute |
| Mean Blood pressure | basal (preoperative), intraoperative each 10 minutes and postoperatively every hour during first 6 hours | mmHg |
Countries
Egypt
Outcome results
None listed