Effect of RIPC on the Prevention of POD in Patients Undergoing Cardiac Surgery

Effects of Remote Ischemic Preconditioning(RIPC) on the Prevention of Postoperative Delirium in Patients Undergoing Cardiac Surgery: A Pilot Randomized Clinical Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05434455

Enrollment

216

Registered

2022-06-28

Start date

2022-07-01

Completion date

2023-12-31

Last updated

2022-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery, Postoperative Delirium

Brief summary

Postoperative delirium (POD) is one of the most frequent neurological complications in elderly patients and is closely associated with longer ICU stay and hospitalization, deterioration of long-term neurocognitive function, and increased mortality. The incidence of POD is significantly higher in elderly patients undergoing cardiac surgery than in other populations. Therefore, the prevention of POD is an important clinical problem to be solved urgently. In this study, we intend to observe the effect of RIPC on the prevention and treatment of POD in patients undergoing cardiac surgery through a prospective randomized controlled trial.

Interventions

DEVICERIPC induced with 3 cycles of 5 minutes of ischaemia and 5 minutes of reperfusion

RIPC was induced with 3 cycles of 5 minutes of ischaemia and 5 minutes of reperfusion on the upper arm. By using blood pressure cuff inflation, patients in the RIPC group were exposed to a pressure 50 mmHg higher than the systolic radial artery pressure baseline.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* patients undergoing elective cardiac surgery; * age ≥ 18 yr; * any sex; * American Society of Anesthesiologists (ASA) class ≥II class; * New York Heart Association (NYHA) ≥II class.

Exclusion criteria

* emergency surgery; * a history of cardiovascular surgery; * peripheral vascular disease affecting the upper limbs; * acute myocardial infarction (MI) up to 14 days before surgery; * a history of severe injuries and operations within 3 months before cardiac surgery; * a history of cancer and chronic autoimmune diseases.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of postoperative delirium	7 days postoperatively or before discharge, whichever came first	Patients were assessed for postoperative delirium by the Confusion Assessment Method (CAM) from the time they were transferred to the ICU at the end of surgery until 7 days postoperatively or before discharge, whichever came first

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026