Colonic Cancer, Prospective Studies, Rectal Cancer
Conditions
Brief summary
1. To establish the Chinese people's own clinical data database of colorectal cancer, reflecting the law and characteristics of colorectal cancer patients in China. 2. Based on colorectal cancer surgery, collect clinical data, especially data on clinical manifestations, complications, laboratory tests, auxiliary examinations, postoperative clinical effects, surgical complications, and colorectal cancer recurrence, so as to lead the direction of clinical practice and academic research of colorectal cancer surgery in China. It provides a certain basis for future research on colorectal cancer. 3. Provide academic consultation and data support to national health authorities.
Interventions
None listed
Sponsors
Beijing Chao Yang Hospital
Peking University People's Hospital
Peking University Cancer Hospital & Institute
Peking Union Medical College Hospital
The First Hospital of Jilin University
Ruijin Hospital
First Hospital of China Medical University
Beijing Friendship Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* adenocarcinoma of the colon by biopsy * tolerable to surgery * be able to understand and willing to participate in this trial with signature
Exclusion criteria
* can not tolerate the surgery * history of serious mental illness * the researchers believe the patients should not enrolled in
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the rate of postoperative complications | 30 days after surgery | preoperative safety containing operation information, complication information. |
| Positive rate of circumferential resection margin (CRM) of the specimens | 10 days after surgery | Circumferential resection margin (CRM) is the distance between the deepest point of tumor in the primary cancer and the margin of resection in the retroperitoneum or mesentery by pathological examination. CRM 0-1mm is defined as positive, while \>1mm is negative. |
| The grade score of the specimens integrity | 10 days after surgery | shows the quality of the specimens: grade 1 is bad gross specimen which means incomplete mesorectum and pelvic fascia, and muscle layer can be see \>5mm; grade 3 is high quality gross specimen, which means the specimen is cylindrical, mesorectum and pelvic fascia are complete; grade 2 is between 1and 3. |
| The distance between lower tumor margin and the lower reaction margin | 10 days after surgery | shows the oncological safety of the surgery by pathological examination. Reports should contain the distance between lower tumor margin and the lower reaction margin. |
| local recurrence rate | 3 years after surgery | show the oncological efficacy by 3-year follow-up according to the NCCN guideline. Participants should report every follow-up examinations which prove tumor recurrence and/or metastasis or not. |
| the operative time | 30 days after surgery | preoperative safety containing operation information, complication information. |
| postoperative hospital stay | 3 year after surgery | recovery information. |
| the score of postoperative life | 6 months after surgery | quality of life contains two scales: Wexner scale and EORTC QLQ-CR29 scale, which show quality of life and the anal function. |
| disease free survival rate | 3-year after surgery | show the oncological efficacy by 3-year follow-up according to the NCCN guideline. Participants should report every follow-up examinations which prove tumor recurrence and/or metastasis or not. |
| overall survival rate | 3-year after surgery | show the oncological efficacy by 3-year follow-up according to the NCCN guideline. Participants should report every follow-up examinations which prove tumor recurrence and/or metastasis or not. |
Countries
China
Contacts
Primary ContactZhongtao Zhang
Backup ContactHongwei Yao
Outcome results
None listed