Intraductal Papillary Mucinous Neoplasm
Conditions
Keywords
intraductal papillary mucinous neoplasm, biomarkers, prospective cohort
Brief summary
This is a prospective, open large cohort study to explore biomarkers for detecting early carcinogenesis of IPMN.
Detailed description
This prospective study was designed to explore biomarkers for detecting early carcinogenesis of IPMN. This study intends to prospectively and continuously enroll IPMN patients, and regularly collect biological samples including blood, urine, feces and saliva. We aimed to detect biomarkers which can predict the carcinogenesis of IPMN by multi-omics. The primary endpoint is the predictive accuracy of biomarkers for IPMN malignant transformation. The probability of IPMN malignant transformation , rates of surgical resection and survival after surgery are secondary endpoints.
Interventions
OTHERObservation
This is an observational study.
Sponsors
The Second Hospital of Hebei Medical University
Second Affiliated Hospital of Nanchang University
Meng Chao Hepatobiliary Hospital of Fujian Medical University
Huizhou Municipal Central Hospital
Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* clinically diagnosed as IPMN; * without other malignant tumor; * agree to sign informed consent.
Exclusion criteria
* with mental disorders which can affect cognition and cooperation; * with serious blood diseases or taking drugs that can affect peripheral blood
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The accuracy of IPMN malignant transformation | Up to 10 years |
Secondary
| Measure | Time frame |
|---|---|
| the probability of IPMN malignant transformation | Up to 10 years |
| rates of surgical resection | Up to 10 years |
| survival after surgery | Up to 10-15 years |
Countries
China
Contacts
Primary ContactTingbo Liang, PhD
Outcome results
None listed