Inflammatory Biomarkers, Neutrophil-lymphocyte Ratio, Posterior Reversible Encephalopathy Syndrome
Conditions
Brief summary
The purpose of this study is to explore the inflammatory biomarkers for the diagnosis of obstetric posterior reversible encephalopathy syndrome.
Detailed description
The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES to explore the inflammatory biomarkers for the diagnosis of oPRES during 2012 to 2021.Then, the investigators grouped all the patients into PRES group (PE or E with PRES) and NOT-PRES group (PE or E without PRES) according to the diagnostic criteria of PRES. Then, the investigators analysed the inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), and so on of two groups, and compared the difference of tow groups.
Interventions
OTHERWhether the PE or E patient combined with PRES
According to the Diagnostic criteria of PRES, all the patients grouped into two groups.
Sponsors
Dunjin Chen
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
16 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. Pregnant women were diagnosed of PE or E. 2. All patients were examined the cranial imaging (MRI or CT), and imaging findings meeting the diagnostic criteria of PRES or normal. 3. all patients provided written informed consent.
Exclusion criteria
1. patients combined with other neurological disorders 2. patients combined with mental illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| inflammatory biomarkers | Inflammatory biomarkers were collected within 1 day after the onset of symptoms. | The values of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio will be measured. |
| cranial Imaging | Cranial Imaging was examined within 3 days after the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment. | According to the cranial Imaging, PE or E patients were grouped into PRES group (typical features presence of vasogenic edema in the white matter of the portions of both cerebral hemispheres) and NOT-PRES group (imaging findings were normal). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| other biochemical parameters | biochemical parameters were collected within 1 week of the hospital stay. | The levels of C-Reactive protein (CRP) will be measured,and CRP﹥8000μg/L means a worse outcome. |
| Blood Pressure(BP) | The BP of patients was obtained within 1hour after the onset of symptoms. | blood pressure including systolic blood pressure (SBP), and diastolic blood pressure (DBP). |
| pregnancy outcomes | The pregnancy outcomes will record immediately when the patients deliver. | The rates of stillbirth and premature birth (gestation less than 37 weeks) in PRES patients. |
Countries
China
Outcome results
None listed