Healthy
Conditions
Brief summary
The purpose of this study is to investigate the associations between human milk nutrients and infants' health outcomes in China.
Detailed description
Human milk components are beneficial to the growth and development of infants, such as phospholipids, gangliosides, sialic acids, choline, oligosaccharide and so on. However, studies on the associations between human milk components and infants' outcomes are limited. Therefore, this study is designed to investigate the relationship between Chinese human milk components and the growth and development of infants.
Interventions
None listed
Sponsors
Huilian Zhu
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Years to 5 Years
Healthy volunteers
No
Inclusion criteria
* age 4-5 years * healthy children * breastfeeding between 0 to 400 days of age * human milk components in human milk being determined * sign informed consent
Exclusion criteria
* children with severe chronic diseases, such as tumor, severe digestive diseases, kidney diseases * gestational diabetes, hypertension and other metabolic diseases * children with mental system diseases * children with congenital and genetic diseases * children with infectious diseases, eg, upper respiratory tract infection or diarrhea * antibiotic or other drugs influencing intestinal flora being taken within 45 days * Withdraw withdraw informed consent serious violation of the scheme no longer meet the research criteria because of health factors or accidents
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The growth of children | 18 month | The physical growth and body composition of children will be checked by physical examination. |
| The cognitive development of children | 18 month | The brain developments of children will be obtained by the Griffith Developmental Assessment Scale. |
| Gut microbiota | 6 month | Gut microbiota of children will be examined by the analysis of 16S rDNA and metagenomic. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Allergic assessment | 18 month | Allergic assessments of children will be conducted by questionnaire. |
| General demographic materials | 14 month | The general demographic materials of parents and children will be obtained by questionnaire. |
| Sleep assessment | 18 month | Sleep assessment of infants will be conducted by The Children's Sleep Health Questionnaire. |
| Dietary and lifestyle information | 3 month | Dietary and lifestyle information of children will be obtained by questionnaire. |
| Behavior problems | 18 month | The behavior problems are collected by Child Behavior Checklist. |
Countries
China
Outcome results
None listed