Cardiovascular Diseases
Conditions
Keywords
Cardiovascular Diseases, Prediction model, Community
Brief summary
To establish and evaluate a new prediction model for assessing cardiovascular disease risk in community-dwelling adults.
Detailed description
This is an ambispective, observational cohort study. In the retrospective part, we will enroll residents from Guangzhou or Foshan who participated in the annual health checks provided by the Chinese National Basic Public Health Service project between January 2015 and December 2019. The demographic characteristics, anthropometric measurements, laboratory assays, medical history, living habits, and medications will be collected through personal electronic health records obtained from the regional chronic disease management platform. In the prospective part, residents who participated in the annual health checks provided by the Chinese National Basic Public Health Service project after January 2020 will be enrolled. In addition to the data collected in the retrospective part, blood, urine and fecal samples and lifestyle questionnaires will be collected for further analysis. All participants will be followed-up till December 2025. A new prediction model for assessing cardiovascular disease risk will be established and evaluated.
Interventions
None listed
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Meet at least one of the following conditions: 1. Age ≥ 65 years; 2. Diabetes mellitus; 3. Hypertension;
Exclusion criteria
* Refuse to provide informed consent;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Major adverse cardiovascular events | 5 years | Major adverse cardiovascular events include all-cause mortality, acute myocardial infarction, coronary heart disease, heart failure and stroke. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | 5 years | Defined as any death after enrollment. |
| Cognitive dysfunction | 5 years | Defined as Montreal Cognitive Assessment (MoCA) Score \< 26 points. |
| Atherosclerotic cardiovascular events | 5 years | Atherosclerotic cardiovascular events include acute myocardial infarction, coronary heart disease, heart failure and fatal and non-fatal stroke. |
| Renal replacement therapy and/or death due to acute renal failure | 5 years | — |
| Incident atrial fibrillation | 5 years | Atrial fibrillation is diagnosed according to the 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation. |
| Renal functional deterioration | 5 years | Evaluated through change in estimated glomerular filtration rate. |
Countries
China
Contacts
Primary ContactJiancheng Xiu, MD
Outcome results
None listed