Osteoarthritis, Knee
Conditions
Keywords
osteoarthritis, responder
Brief summary
This is a pilot study with a 4-period double-cross-over design evaluating a treatment with non-steroidal anti-inflammatory drugs (NSAIDs) in people with painful knee osteoarthritis.
Detailed description
Once screened and found eligible, participants will be entered into an initial blinded 2-week treatment period of either naproxen or placebo and then entered into an open washout period of 2 weeks. At the end of this washout, participants will then receive either naproxen or placebo for a further 2 week period followed again by a 2 week washout. This sequence will then be repeated (total of 4 treatment periods) such that all participants receive naproxen for 2 treatment periods and placebo for 2 treatment periods. The order of treatment will be randomized.
Interventions
DRUGNaproxen 500 Mg
naproxen tablets
DRUGPlacebo
lactose NF
Sponsors
Northwestern University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
All medication will be prepared in capsules identical in appearance and weight.
Intervention model description
Participants will be entered into the trial and have an initial blinded 2-week treatment period of either naproxen or placebo and then entered into an open washout period of 2 weeks. At the end of this washout, participants will then receive either naproxen or placebo for a further 2 week period followed again by a 2 week washout. This sequence will then be repeated (total of 4 treatment periods) such that all participants receive naproxen for 2 treatment periods and placebo for 2 treatment periods. The order of treatment will be randomized and the treatment allocation and IP will be blinded.
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Male or female \>40 years of age 2. Meet ACR criteria for knee OA 3. Able and willing to provide informed consent 4. Average weekly pain in the index knee based on daily pain assessments of ≥ 4/10 and \<9/10 on an 11-point NRS scale 5. Willing to discontinue current medications taken for OA pain 6. For women of child-bearing potential, willing to utilize some form of birth control or abstinence during the course of the study 7. If taking cannabinoids, have to be on a stable dose and have this maintained for the duration of the study 8. If receiving physical therapy or any non-pharmacologic modality(ies) for OA, these need to continue and remain stable for the duration of the study 9. Ambulatory 10. Have a cellphone and/or access to a computer and be able to utilize the eDiary as directed 11. Use of medications for knee OA pain on at least 4 out of 7 days per week 12. eDiary entries on at least 4 out 7 days per week during the observation period 13. Sub-Group Criterion (≥12 participants): Variability of average daily pain in the index knee during the observation period of ≥ 2 points on the NRS scale on at least 4 occasions
Exclusion criteria
1. History of intolerance or allergic reaction to NSAIDs 2. Previous history of GI bleed 3. Renal insufficiency resulting in serum creatinine \> 1.5 mg/dL 4. History of myocardial infarction in last 6 months 5. Coexisting congestive heart failure or symptomatic atherosclerotic heart disease 6. Use of oral anticoagulants other than aspirin ≤ 325 mg for cardiac prophylaxis 7. Use of heparin or injectable anticoagulant 8. Uncontrolled hypertension 9. Any medical condition which in the judgement of the investigator would make it inappropriate for the participant to enroll in the study 10. Use of recreational drugs 11. Fibromyalgia 12. Inflammatory arthropathies of any sort 13. Chronic back pain in which pain level is greater than the OA pain 14. Participation in another clinical trial other than one for covid or an observational and non-interventional study 15. Use of walker or other aid for walking other than a single cane 16. Hip pain on the ipsilateral side equal to or greater than the knee pain in the index joint 17. Index knee cannot have had previous joint replacement surgery 18. Arthroscopy within the past 6 months 19. Injection of hyaluronate in the index knee in the past 6 months 20. Corticosteroid injection in the index knee in the past 3 months 21. Injection of any biologic agent in the index in the past 12 months 22. Nerve ablation for the treatment of pain in the index knee 23. Any acute or chronic pain condition which would interfere with the evaluation of knee pain. 24. Pregnant, nursing or planning to become pregnant during length of study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean of one week's daily pain ratings on Numeric Pain Scale (NRS) 0-10; higher worse | baseline to end of 14 day treatment period | daily pain will be collected by a web application and averaged over a 7day period; higher scores imply more pain |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORThomas J Schnitzer, MD, PhD
Northwestern University
Outcome results
None listed