Healthy
Conditions
Keywords
Theta-Burst stimulation (iTBS), Functional near-infrared spectroscopy (fNIRS), Concurrent TMS/fNIRS, Prefrontal hemodynamic response, Longitudinal effects
Brief summary
This study will investigate the effect of caffeine and time of day on brain excitability using excitatory brain stimulation. The investigators will recruit a healthy participant and conduct a concurrent iTBS/fNIRS protocol for 20 consecutive sessions over four weeks with or without caffeine consumption before the stimulation. Moreover, the experiment will be conducted at different times of the day (morning or afternoon)
Detailed description
One healthy participant will be recruited for this study. The participants will be subjected to concurrent TBS/fNIRS, to which the iTBS will be applied on the left DLPFC and the NIRS will measure the prefrontal hemodynamic response simultaneously.
Interventions
OTHERExperimental time
The investigators will ask participant to attend the experiment in the morning or afternoon
OTHERcaffeine
The investigators will ask participant to only intake 200 mg of caffeine one hour before the experiment (no other caffeine intake since the wake-up) or avoid caffeine intake at all before the experiment
Sponsors
The Hong Kong Polytechnic University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
One healthy participant will undergo four weeks of concurrent TBS/fNIRS to investigate the cortical hemodynamic variability
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Right-handed
Exclusion criteria
* history of epilepsy, seizures, or convulsions * current or past diagnosis of neurological disorders, such as head injuries, strokes, encephalitis, epilepsy, Parkinson's, or Alzheimer's * current or past diagnosis of psychiatric disorders, such as depression, anxiety, schizophrenia, or autism * with metal implants, such as a cochlear implant, neurostimulator, or cardiac pacemaker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxygenated hemoglobin (HbO) change compared to baseline | During and post TBS-fNIRS measurement, up to 1 month | iTBS-induced HbO change in the DLPFC before, during and after stimulation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Deoxygenated hemoglobin (HbR) change compared to baseline | During and post TBS-fNIRS measurement, up to 1 month | iTBS-induced HbO change in the DLPFC before, during and after stimulation |
| Oxygen saturation change compared to baseline | During and post TBS-fNIRS measurement, up to 1 month | iTBS-induced HbO change in the DLPFC before, during and after stimulation |
Countries
Hong Kong
Outcome results
None listed