Blood Loss, Surgical
Conditions
Brief summary
investigator will see the efficacy of tranexamic acid in limb salvage surgery patients which will prevent blood loss and help in conservation of blood products.
Interventions
DRUGTranexamic acid injection
will inject tranexamic acid in limb salvage surgery of sarcoma patient to check its efficacy in preventing blood loss
OTHERnormal saline
normal saline will be injected to ensure placebo
Sponsors
Shaukat Khanum Memorial Cancer Hospital & Research Centre
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Limb sarcoma of upper and lower limb * Limb salvage
Exclusion criteria
* liver insufficiency * renal insufficiency * allergic to drug * history of thromboembolic condition * pregnancy * metastatic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood loss | 72 hour post operatively | measure by hemoglobin direct method |
| no of blood transfused | 72 hour | measured by number of transfusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| duration of hospital stay | total hospital stay post operatively for 02 month | Total days of hospital admission 2 months after surgery |
| volume of drain out put | measure till drain out in 72 hour | to measure blood collected in drain bottle |
| thromboembolic events | observed for 6 week determine on out patient visits | look for limb swelling for deep vein thrombosis and chest symptoms for any embolic event confirmed by CT chest |
Countries
Pakistan
Contacts
Primary Contactmuhammad bilal shafiq, fcps
Outcome results
None listed