Motor Neuropathy
Conditions
Keywords
motor function recovery, ischemic stroke, EEG-fMRI, neural plasticity
Brief summary
This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.
Detailed description
A group of patients with ischemic stroke and age/gender matched healthy controls would be enrolled in this study. Their features of neural activities based on EEG-fMRI fusion scan would be extracted to investigate the mechanisms of motor recovery after stroke. Particularly, the correlations of their features of neural networks or local activities to their motor function (defined as their Fugl-Meyer scores) at enrollment and their recovery time courses consisted of Fugl-Meyer scores in follow-up time points. Data of T1 structural, DSI fiber image and pure EEG (without MRI) would also be collected along with EEG-fMRI fusion data.
Interventions
DIAGNOSTIC_TESTMRI recording
MRI imaging was performed using a 3 Tesla Siemens Prisma system with a 64-channel head/neck coil (Siemens Medical Systems, Erlangen, Germany). The MRI protocols included as follows: (i) Magnetization-Prepared 2 Rapid Acquisition Gradient Echoes: TR/TE/ TI1/TI2 = 5000/2.98/700/2500 ms, voxel size = 1.0 × 1.0 × 1.0 mm3, FOV = 256 × 240 × 176 mm3; (ii)Gradient-echo EPI: TR 720 ms, TE 33.1 ms, flip angle 52 deg, FOV 208x180 mm, Matrix 104x90, Slice thickness 2.0 mm; 72 slices; 2.0 mm isotropic voxels, Multiband factor 8, Echo spacing 0.58 ms, BW 2290 Hz/Px; (iii) DSI : TR/TE = 3300/73 ms, FOV = 220 × 220 × 60 mm3, voxel size = 2 × 2 × 2 mm3, 128 diffusion direction, b-max = 3000 sec/mm2, AT = 7:22 min); (iv) T2-weighted fluid-attenuated inversion recovery: TR/TE = 9000/84 ms, FOV = 270 × 320 × 22 mm2, voxel size = 0.72 × 0.72 × 6.6 mm3.
DIAGNOSTIC_TESTEEG recording
EEG was performed using a BrainAmp MR 32 amplifier (BrainProducts GmbH, München, Germany). The EEG protocols included as follows: (i) EEG-fMRI fusion: Sampling rate: 5000 Hz, low cut off-high cut off: DC-1000Hz;(2) EEG-fMRI fusion: Sampling rate: 1000 Hz, low cut off-high cut off: DC-1000Hz. In (i) an ECG channel would be used to collect artifact of pulse and not used in (ii).
Sponsors
Xian Daxing Hospital
Xi'an Jiaotong University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Age above 18 and below 75 years * Motor impairment in National Institutes of Health Stroke Scale * 7-14 days since stroke attack * First-ever ischemic stroke
Exclusion criteria
* Motor impairment induced by non-stroke aetiology * Claustrophobia; recognition disorder * History of other severe central nervous system diseases * Any signs unfit for MRI/EEG scan
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fugl-Meyer scores (T3) | 72 weeks since stroke | a scale widely used to evaluate one's motor impairment |
| Fugl-Meyer scores (T0) | 7-14 days since stroke | a scale widely used to evaluate one's motor impairment |
| Fugl-Meyer scores (T1) | 6 weeks since stroke | a scale widely used to evaluate one's motor impairment |
| Fugl-Meyer scores (T2) | 12 weeks since stroke | a scale widely used to evaluate one's motor impairment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neuroimage features based on EEG-fMRI (T0) | 7-14 days since stroke | Neuroimage features extracted from EEG-fMRI data |
| Neuroimage features based on EEG-fMRI (T1) | 6 weeks since stroke | Neuroimage features extracted from EEG-fMRI data |
| Neuroimage features based on EEG-fMRI (T2) | 12 weeks since stroke | Neuroimage features extracted from EEG-fMRI data |
| Neuroimage features based on EEG-fMRI (T3) | 72 weeks since stroke | Neuroimage features extracted from EEG-fMRI data |
Countries
China
Outcome results
None listed