Exercise, Healthy Male Subjects
Conditions
Keywords
Whey protein, Collagen peptide, Muscle and tendon overload training
Brief summary
The aim of the study is to investigate the acute and short-term effects of collagen peptides (Collagen Peptan) on muscle and connective tissue during an eccentric overload training period. Currently, all studies investigating the effects of post-exercise collagen supplementation did this in the absence of whey proteins, which are part of the standard recommendations for post-exercise recovery. The investigators will therefore investigate whether the combined intake of whey proteins and collagen peptides ensures a better recovery of exercise performance and whether it can prevent or reduce symptoms of muscle and tendon overload during a three-week eccentric overload training period (n = 22).
Interventions
DIETARY_SUPPLEMENTwhey protein
Daily 45g of whey protein supplementation during a three week eccentric training period
DIETARY_SUPPLEMENTwhey protein + collagen peptide
Daily 15g of whey protein and 20g collagen peptide supplementation during a three week eccentric training period
Sponsors
Rousselot BVBA
KU Leuven
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Sports participation, including general fitness training, between 2 and 5 hours max per week * Body mass index between 18.5 and 25
Exclusion criteria
* Any kind of injury/pathology that is a contra-indication to perform high-intensity exercise - Intake of any medication or nutritional supplement that could impact muscle protein synthesis and/or exercise performance during the period of the study * Intake of any whey protein, casein of branched-chain amino acid (BCAA) supplements from 1 month prior to the start of the study * Blood donation within 3 months prior to the start of the study * Smoking * Current participation in another research trial * Any other argument to believe that the subject is unlikely to successfully complete the full study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in countermovement jump performance | Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention) | Change in jump height when performing a countermovement jump, measured via a force platform |
| Change in maximal isometric knee-extension force of the right leg | Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention) | Change in maximal isometric knee-extension force (angle = 45°) of the right leg |
| Change in anteroposterior thickness of the right patellar tendon | Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention) | Change in anteroposterior thickness of the right patellar tendon |
| Change in neovascularization of the right patellar tendon | Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention) | Neovascularization of the right patellar tendon scored with the Modified Ohberg Score (range 0 - 4; the higher the score, the higher the degree of neovascularization). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in pain perception at the muscular level (VAS scale) | Training 1 (day 1 of training intervention) - Training 2 (day 3 of training intervention) - Training 8 (day 9 of training intervention) - Training 17 (day 19 of training intervention) - Posttest (day 22 of training intervention) | Change in pain perception at the muscular level of the right leg, measured via the Visual Analogue Scale (range 0 - 10; the higher the score, the higher the pain level) |
| Change in the blood concentration of N-terminal propeptide of type I procollagen (P1NP) | Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention) | Change in blood concentration of N-terminal propeptide of type I procollagen (P1NP; marker of collagen synthesis) |
| Change in pain perception of the patellar tendon of the right leg (VISA-P) | Pretest - Training 1 (day 1 of training intervention) - Training 17 (day 21 of training intervention) - Posttest (day 22 of training intervention) | Change in pain perception of the patellar tendon of the right leg, measured via the VISA-P questionnaire (range: 0 - 100; the lower the score, the higher the symptoms of patellar tendon overload) |
| Change in the blood concentration of creatine kinase | Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention) | Change in blood concentration of creatine kinase (marker of muscle damage) |
| Change in the blood concentration of Interleukin 6 (IL-6) | Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention) | Change in blood concentration of Interleukin 6 (IL-6; marker of inflammation) |
Countries
Belgium
Outcome results
None listed