Non-Small Cell Lung Cancer
Conditions
Keywords
Extracellular Vesicles and Particles, Biomarkers, 22-155
Brief summary
The purpose of this study is to find out if fluid rinsed from peoples' airways (bronchial washing samples) during routine surgery to remove (resect) their non-small cell lung cancer (NSCLC) tumors contains enough vesicles to do testing that may help the researchers learn more about their NSCLC.
Interventions
None listed
Sponsors
Memorial Sloan Kettering Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients ≥ 18 years of age undergoing consideration of surgical resection, including lobar resections, sublobar resections, and pneumonectomies, for primary lung cancer will be eligible. * Patients with previously resected disease and/or previous radiation therapy will be considered on a case by case basis.
Exclusion criteria
* Patients with active infection or pneumonia which may impact exosome makeup * Additionally, if at the discretion of the operating surgeon, obtaining bronchial washings would lead to undue morbidity, the patient would be excluded and replaced
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| to isolate exosomes from bronchial washings | day 1 | every patient from whom the essential specimens have been acquired will be evaluated to determine if more than 100,000 microvesicles can be isolated for exosome purification |
Countries
United States
Contacts
CONTACTDavid Jones, MD
CONTACTYuan Liu, MD, PhD
PRINCIPAL_INVESTIGATORDavid Jones, MD
Memorial Sloan Kettering Cancer Center
Outcome results
None listed