Diets, Lipoproteins and Inflammation Markers

Effectiveness of Vegan Diet and MyPlate Diet (Taiwanese Version) on Lipoproteins, Novel Markers of Cardiovascular Diseases, and Traditional Cardiometabolic Risk Factors

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05423457

Enrollment

Registered

2022-06-21

Start date

2017-07-18

Completion date

2018-06-15

Last updated

2023-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases, Diet, Healthy, Inflammatory Response, Metabolic Syndrome, Vegan Diet

Brief summary

Systematic inflammation and lipid profiles are two major therapeutic targets for cardiovascular diseases. The effectiveness of vegan diet has been reported (doi: 10.3389/fnut.2022.807810). Aim: To compare the effectiveness of a nutritionally balanced vegan diet and a Myplate diet ((Taiwanese version) on systematic inflammation and lipoprotein subclass. Design: Randomized crossover design

Interventions

BEHAVIORALVegan diet

The participants were advised to eat foods in their original type.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 75 Years

Healthy volunteers

Inclusion criteria

Patients with dyslipidemia (at least one of the following) * TG ≥ 150 mg/dL * TC ≥ 200 mg/dL * LDL-c≥ 130 mg/dL, * HDL-c \< 45 mg/dL for male or \< 55 mg/dL for female or receiving statin treatment

Exclusion criteria

(fulfill one of the following condition): * chronic kidney disease * history of coronary artery disease * ischemic heart disease, * heart failure, * stroke, * cancer of any type

Design outcomes

Primary

Measure	Time frame	Description
Novel inflammatory markers for cardiovascular disease and Lipoprotein particles concentration	12 weeks	GlycA (umol/L), lipoprotein particles concentration(umol/L)
Lipoprotein particles concentration	12 weeks	lipoprotein particles concentration (nmol/L）
lipoprotein particles size	12 weeks	lipoprotein particles size (nm)
Trimethylamine-N-oxide	12 weeks	TMAO (uM). TMAO is a low molecular weight compound that belongs to the class of amine oxides
Traditional cadiometabolic risk factors 1	12 weeks	TG(mg/dL), LDL-C(mg/dL), HDL-C(mg/dL), Total cholesterol(mg/dL)
Traditional cadiometabolic risk factors 2	12 weeks	HbA1c(%)
Traditional cadiometabolic risk factors 3	12 weeks	HOMA-IR index (Homeostasis Model Assessment-Insulin Resistance index)

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026