Carpal Tunnel Syndrome
Conditions
Brief summary
Carpal tunnel syndrome is the most common peripheral entrapment neuropathy of the upper limb. Previous experiments found that ultrasound-guided median nerve hydrodissection with 5% dextrose water could ameliorate the condition of carpal tunnel syndrome. Oral administration of vitamin B 12 had been reported to reduce the discomfort from peripheral neuropathy although the level of evidence is not strong. This prospective, double-blind randomized control trial aims to compare the effects of different kinds of the injection agents on carpal tunnel syndrome.
Interventions
Peri- median nerve injection for hydrorelease and decompression
Sponsors
National Cheng-Kung University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age between 20-80 year-old. * Diagnosis (carpal tunnel syndrome) was confirmed using an electrophysiological study.
Exclusion criteria
* Previously undergone wrist surgery or steroid injection for CTS * Thrombocytopenia * Coagulopathy * Inflammation status * Polyneuropathy * Brachial plexopathy * Cervical radiculopathy * Autoimmune disease * Malignancy * Pregnancy Thoracic outlet syndrome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Boston Carpal Tunnel Syndrome Questionnaire | Pre-treatment, 1st, 3rd, 6th month after injection | Measure the severity of symptoms and functional status before and after treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Visual analog scale of pain and tingling | Pre-treatment, 1st, 3rd, 6th month after injection | Measure the pain and tingling scale before treatment and after treatment. (0 is for not at all pain/tingling, and 100 is for extremely pain/tingling.) |
| Cross-sectional area of the median nerve | Pre-treatment, 1st, 3rd, 6th month after injection | Using the ultrasound to measure the cross-sectional area of the median nerve before and after treatment |
| Median nerve elastography | Pre-treatment, 1st, 3rd, 6th month after injection | Using the ultrasound to measure the elastography of the median nerve before and after treatment |
| Median nerve conduction velocity and amplitude | Pre-treatment, 1st, 6th month after injection | Antidromic sensory nerve conduction velocity and amplitude of the median nerve before and after treatment |
Countries
Taiwan
Contacts
Primary ContactYao-Hong Guo, MD, MSc
Outcome results
None listed