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Early Goal-Directed Therapy Utilizing Transpulmonary Thermodilution and Severe Burn Injury

Early Goal-Directed Therapy Utilizing Transpulmonary Thermodilution for Treating Adult Patients With Severe Burn Injury

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05420610
Enrollment
66
Registered
2022-06-15
Start date
2021-08-07
Completion date
2022-01-20
Last updated
2022-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burns

Brief summary

This study aimed to optimize fluid resuscitation with transpulmonary thermodilution (TPTD)-guided protocol and to lower the mortality rate of the severely burned.

Interventions

OTHERControl group: Patients being admitted when The advancement of transpulmonary thermodilution(TPTD) device was unavailable.

The control group included patients being admitted when TPTD device was unavailable; and relatively stable patients without the need for TPTD. The adequacy of fluid resuscitation in the control group was monitored by traditional monitoring parameters including vital signs and hourly urine output.

OTHERStudy group: TPTD device was implemented for monitoring.

TPTD device was implemented for monitoring; the inclusion criteria included patients suffering from 2nd degree burn greater than 40% TBSA; a combined 2nd to 3rd degree burn greater than 30% TBSA; or patients with inhalation injury despite the burned surface area.

Sponsors

Chang Gung Memorial Hospital
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No

Inclusion criteria

* Adult patients (age \> 18 years). * Major burn (as total burned surface area (TBSA) \> 20% with at least second degree burn depth). * Admitted to the intensive care unit (ICU) of the Burn Center.

Exclusion criteria

* Patients younger than 18 years old. * Patients with severe cardiopulmonary diseases, or associated with other major trauma. * Patient with incomplete data.

Design outcomes

Primary

MeasureTime frameDescription
Patient mortalityUp to 6 monthsThe primary outcome was patient mortality after major burn.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026