Colorectal Cancer
Conditions
Brief summary
The purpose of this study is to determine the frequency of colorectal cancer in male and female endurance athletes between the ages of 35 and 50.
Interventions
OTHERprospective observational study - screening and follow up colonoscopy
Involves two visits and a colonoscopy. The first visit will be prior to the colonoscopy. 4-35 days after the colonoscopy, there will be a one time appointment to go over the results of the colonoscopy.
Sponsors
Inova Health Care Services
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Adult males and females 35-50 years of age * Male and female self-reported endurance athletes, defined by at least one of the following: * Run at least two races of 50 miles or more * Run 5 races of 26.2 miles or more * Ability to complete testing in the protocol and make study visits * Able and willing to consent to protocol
Exclusion criteria
* Known or suspected history of inflammatory bowel disease, familial adenomatous polyposis (FAP), or Lynch Syndrome * Concomitant illness that would prevent adequate patient assessment or in the investigators' opinion pose an added risk for study participants. * Anticipated poor compliance * Prisoners or subjects who are involuntarily incarcerated * Persons with decisional incapacity/cognitive impairment * Any history or evidence of severe illness or any other condition that would make the patient, in the opinion of the investigator unsuitable for the study * Subject is involved with a worker's compensation, personal injury, or other legal matters related to their health * Subject is enrolled in a separate interventional clinical trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The rate of young endurance runners' that have adenomatous polyps. | 36 months | 1. Estimate the rate of young endurance runners that have adenomatous polyps. 2. Estimate the rate of young endurance runners that have advanced adenoma and colorectal cancer on screening colonoscopies. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of the rate of young endurance athletes that have adenomatous polyps with that of the historical controls (those in the average risk group). | 36 months | Fisher's Exact test will be used to compare the rates of adenomatous polyps and colorectal cancer between the young endurance athletes and that of the historical controls. 2.3 Secondary Objectives 1. Compare the rate of young endurance runners that have adenomatous polyps with that of the historical controls (those in the average risk group) 2. Compare the rate of young endurance runners that have advanced adenoma and colorectal cancer on screening colonoscopies with that of the historical controls (those in the average risk group). |
| Comparison of the rate of young endurance athletes that have colorectal cancer on screening colonoscopies with that of the historical controls (those in the average risk group). | 36 months | Fisher's Exact test will be used to compare the rates of adenomatous polyps and colorectal cancer between the young endurance athletes and that of the historical controls. |
Countries
United States
Outcome results
None listed