Dialysis; Complications
Conditions
Keywords
hemodialysis, recovery time, dialysate Na
Brief summary
This research aims to assess the effect of low versus high dialysate sodium concentration during hemodialysis on dialysis recovery time
Detailed description
Chronic kidney disease (CKD) is a general term for heterogeneous disorders affecting the structure and function of the kidney. The variation in disease expression is partly related to the cause, pathology, severity and the rate of progression. Fatigue is a well-known and frequent symptom in HD patients with a reported association with the decrease in health-related quality of life commonly found in this population. The prevalence of fatigue ranges from 60% to as high as 97% in patients on long-term renal replacement therapy. Despite this fact, health care providers are still unaware of both its presence and severity. Several methods have been proposed as a way to assess post-HD fatigue with the time to recover (minutes) from HD being one of them. Lindsay et al.assisted patients' responses to the single open-ended question, How long does it take you to recover from a dialysis session?. Although post-HD fatigue commonly exists in dialysis patients, it is usually underestimated by physicians. For this reason, appropriate and early identification of symptoms and associated factors might improve the patient's quality of life. Rayner et al. found that dialysate Na was inversely associated with DRT where lowering the Na concentration in the dialysate (to 140 mEq/L) was linked to a longer DRT.
Interventions
OTHERlow dialysate Na
low dialysate sodium (Na = 136 mmol/L) for 8 weeks
OTHERhigh dialysate Na
high dialysate sodium (Na = 141 mmol/L) for 8 weeks
Sponsors
Alexandria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
a single blinded study as participants will be unaware about the dialysate Na each patient receives
Intervention model description
This research is a single-blinded randomized clinical trial in which 40 haemodialysis patients will be randomly assigned to one of the study groups using block randomization with a ratio of 1:1.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with end-stage renal disease who have been prescribed long term hemodialysis and undergo four-hour HD treatments three times a week for more than 90 days. * Patient must be at least 18 years old. They must be able to read and write, as well as be in complete mental health.
Exclusion criteria
* Inability to complete the surveys due to reading or hearing difficulties, actual instability of clinical condition that necessitate hospitalization, dementia, active malignancy or liver failure.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in dialysis recovery time | baseline, weeks 4 and 8 | By assessing the patients' responses to the single open-ended question, How long does it take you to recover from a dialysis session? |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in the inter-dialytic weight gain | 8 weeks | measuring the inter-dialytic weight gain |
| Change in blood pressure (systolic, diastolic, mean) | 8 weeks | measuring in blood pressure (systolic, diastolic, mean) |
| Change in plasma sodium concentration | baseline, weeks 4 and 8 | measuring plasma sodium concentration |
| Occurrence of muscle cramps | 8 weeks | incidence of muscle cramps |
| Occurrence of headache | 8 weeks | incidence of headache |
| Occurrence of intradialytic hypotension | 8 weeks | incidence of intradialytic hypotension |
Countries
Egypt
Contacts
Primary ContactMohamed Mamdouh Elsayed, MD
Outcome results
None listed