Allergy
Conditions
Keywords
post-intervention, allergic manifestations
Brief summary
The present study is a 5-year follow-up of the Allergy Reduction Trial (A.R.T.) birth cohort study of 551 infants at high-risk for allergy. The A.R.T. 5-year follow-up study, aims to investigate the prolonged effect of each feeding regimen \[formula-fed (exclusively or partially) with the partially hydrolyzed formula (pHF) or the standard formula (SF), or exclusively breastfed\] within the first 6 months of life on the development of any allergic manifestations up to the age of 5 years. Allergic manifestations within this time period will include the presence of any of the following: atopic dermatitis, food allergies, respiratory allergies, urticaria, drug allergy and insect venom allergy. In addition, differences on growth (weight, height, BMI) will be examined.
Detailed description
The present study is a 5-year follow-up of the Allergy Reduction Trial (A.R.T.) birth cohort study of 551 infants at high-risk for allergy. The A.R.T. 5-year follow-up study, aims to investigate the prolonged effect of each feeding regimen \[formula-fed (exclusively or partially) with the partially hydrolyzed formula (pHF) or the standard formula (SF), or exclusively breastfed\] within the first 6 months of life on the development of any allergic manifestations up to the age of 5 years. Allergic manifestations within this time period will include the presence of any of the following: atopic dermatitis, food allergies, respiratory allergies, urticaria, drug allergy and insect venom allergy. In addition, differences on growth (weight, height, BMI) will be examined.
Interventions
OTHERNo intervention is used in the current study. Interventions were given in the original A.R.T. study
The current study is a post-intervention study; interventions were given in the original A.R.T. study
Sponsors
FrieslandCampina
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
5 Years to 63 Months
Healthy volunteers
No
Inclusion criteria
* Children who were part of the Intention-to-Treat population of the A.R.T. study * Children of the A.R.T. study ITT population within the age range of 5 years up to 5 years and 3 months * Children of the A.R.T. study ITT population in whom at least one parent and/or legal guardian signed the written consent form
Exclusion criteria
* Children who did not participate in the A.R.T. study or who were not assigned to any of the 3 study arms * Children of the A.R.T. study who are younger than 5 years of age or older than 5 years and 3 months of age * Children of the A.R.T. study in whom parents and/or guardians do not agree to provide a written consent form
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of allergic Manifestations | At 5 years of age | Incidence of allergic manifestations (AM) based on parental reporting using Childhood Allergy questionnaire comparing partially hydrolyzed protein formula, standard formula and exclusive breastfeeding. |
Countries
Bulgaria, Cyprus, Greece
Outcome results
None listed