Observation of the Natural Course of Age-related Macular Degeneration

Observation of the Natural Course of Dry Age-related Macular Degeneration

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05418231

Enrollment

500

Registered

2022-06-14

Start date

2022-07-31

Completion date

2027-07-31

Last updated

2022-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry Age-related Macular Degeneration, Macular Degeneration, Dry

Brief summary

This research will study natural course of dry AMD in Chinese population, screen fundus imaging indicators for patients with Chinese dry AMD, describe the clinical features of Chinese patients with dry AMD, and obtain a biological sample library of dry AMD mainly in China.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to 85 Years

Healthy volunteers

Inclusion criteria

* 50-85 yrs male or female AMD patients * Dry-AMD patients in either early, intermediate, or intermediate-to-late stage confirmed by fundus examinations.

Exclusion criteria

* Any eye with disease that would interfere with the retinal examinations * Research eye with CNV or high myopia * Surgeries that may interfere with AMD evaluation * Long-term uses of medications that are associated with retinal or neural toxicities. * IOP more than 26 mmHg * Received cataract surgery in 3 months. * Other conditions: diseases that causes less than 5 years survival; any condition that causes high risk of drop-out, or low compliance, for instance cognition disorder; have been involved in other trial that interfere with the current visit plan; taking other angiogenesis Inhibitors drugs for treating cancer. * Other conditions not suitable for the current study

Design outcomes

Primary

Measure	Time frame	Description
Visual acuity	60 months	A typical ETDRS chart that if frequently used for visual acuity testing

Secondary

Measure	Time frame	Description
Drusen density and shape	60 months	Drusen Measurement on OCT or Fundus photography
The rate of 5-year progression	60 months	The evaluation criteria for progression: progress to intermediate (only for patients with early phase AMD at baseline) or intermediate-to-late, or late stage AMD.
GA growth rate	60 months	—

Countries

China

Contacts

Primary ContactJunran Sun, M.D.

emiliesun@sina.com+8613661995933

Outcome results