Acute Psychological Stress
Conditions
Brief summary
The present study will examine cardiovascular, metabolic, and neural responses to acute psychological stress using a cross-sectional approach.
Detailed description
All participants in this study will undergo an acute psychological stress paradigm, consisting of two acute psychological stress tasks (MSIT and Stoop). There is no formal randomization since al participants are randomized to undergo the acute psychological stress tasks.
Interventions
OTHERAcute psychological stress
Experimental: Acute psychological stress Two, acute-psychological stress tasks known to reliably elicit a cardiovascular responses (Multi-source interference task; Stroop).
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
Baylor University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-30 years old
Exclusion criteria
* Chronic medical or neurological condition * Pregnant * Current illness or infection * Any condition that would prohibit engaging in physical exercise * Any metal implants in body * Claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline) | 18 minutes (approximately 9 minutes for each task) | Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline). |
| Heart Rate (Bpm) Measured by Electrocardiogram | 18 minutes (approximately 9 minutes for each stress task) | Stressor-evoked heart rate. (Heart rate during acute psychological stress task - Heart rate during resting baseline). |
| Neural Activity Measured by fMRI | 18 minutes (approximately 9 minutes for each stress task). | Stressor-evoked neural activity. Incongruent-vs-Congruent t at the group-level, filtered at 0.05 after FDR correction and with a cluster extent of 50 voxels. |
Countries
United States
Participant flow
Recruitment details
Recruited in Waco, Texas area
Pre-assignment details
All participants engaged in the acute psychological stress task.
Participants by arm
| Arm | Count |
|---|---|
| Acute Psychological Stress Participants will undergo an acute psychological stress task that has been shown to elicit neural, cardiovascular, and psychological (feelings of stressfulness) responses.
Acute psychological stress: Participants will undergo an acute psychological stress task that has been shown to elicit neural, cardiovascular, and psychological (feelings of stressfulness) responses. | 170 |
| Total | 170 |
Baseline characteristics
| Characteristic | Acute Psychological Stress |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 170 Participants |
| Age, Continuous | 22.08 years STANDARD_DEVIATION 2.93 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 38 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 132 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 3 Participants |
| Race (NIH/OMB) Asian | 30 Participants |
| Race (NIH/OMB) Black or African American | 21 Participants |
| Race (NIH/OMB) More than one race | 13 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 103 Participants |
| Region of Enrollment United States | 170 Participants |
| Sex: Female, Male Female | 87 Participants |
| Sex: Female, Male Male | 83 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 170 |
| other Total, other adverse events | 0 / 170 |
| serious Total, serious adverse events | 0 / 170 |
Outcome results
Primary
Heart Rate (Bpm) Measured by Electrocardiogram
Stressor-evoked heart rate. (Heart rate during acute psychological stress task - Heart rate during resting baseline).
Time frame: 18 minutes (approximately 9 minutes for each stress task)
Population: Data loss for 3 participants due to equipment malfunction.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Acute Psychological Stress Task | Heart Rate (Bpm) Measured by Electrocardiogram | Stroop task | 4.926 beats per minute (bpm) | Standard Deviation 7.456 |
| Acute Psychological Stress Task | Heart Rate (Bpm) Measured by Electrocardiogram | MSIT | 2.826 beats per minute (bpm) | Standard Deviation 6.317 |
Primary
Neural Activity Measured by fMRI
Stressor-evoked neural activity. Incongruent-vs-Congruent t at the group-level, filtered at 0.05 after FDR correction and with a cluster extent of 50 voxels.
Time frame: 18 minutes (approximately 9 minutes for each stress task).
Population: Participants who have full data for both acute psychological stress tasks during fMRI scanning.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Parietal_inf (stroop) | 0.71 BOLD signal (Incon - Con) | Standard Error 0.41 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Angular (stroop) | 0.54 BOLD signal (Incon - Con) | Standard Error 0.35 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Supp_Motor_Area (stroop) | 1 BOLD signal (Incon - Con) | Standard Error 0.65 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Frontal_Inf_Tri (stroop) | 0.85 BOLD signal (Incon - Con) | Standard Error 0.56 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Parietal_Inf2 (stroop) | 0.66 BOLD signal (Incon - Con) | Standard Error 0.45 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Insula (stroop) | 0.70 BOLD signal (Incon - Con) | Standard Error 0.5 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Frontal_Inf_Oper (stroop) | 0.76 BOLD signal (Incon - Con) | Standard Error 0.6 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Vermis (stroop) | 0.84 BOLD signal (Incon - Con) | Standard Error 0.68 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Thalamus (stroop) | 0.48 BOLD signal (Incon - Con) | Standard Error 0.4 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Precuneus2 (stroop) | -0.55 BOLD signal (Incon - Con) | Standard Error 0.52 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L ParaHippocampal2a (stroop) | -0.47 BOLD signal (Incon - Con) | Standard Error 0.5 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Angular2 (stroop) | -0.49 BOLD signal (Incon - Con) | Standard Error 0.54 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Frontal_Med_Orb2 (stroop) | -1.38 BOLD signal (Incon - Con) | Standard Error 1.57 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Frontal_Sup2 (stroop) | -0.55 BOLD signal (Incon - Con) | Standard Error 0.66 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L ParaHippocampal2 (stroop) | -0.47 BOLD signal (Incon - Con) | Standard Error 0.58 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R ParaHippocampal2 (stroop) | -0.35 BOLD signal (Incon - Con) | Standard Error 0.46 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Precentral2 (stroop) | -0.20 BOLD signal (Incon - Con) | Standard Error 0.31 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Rolandic_Oper2 (stroop) | -0.19 BOLD signal (Incon - Con) | Standard Error 0.33 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Angular2 (stroop) | -0.23 BOLD signal (Incon - Con) | Standard Error 0.45 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Amygdala2 (stroop) | -0.21 BOLD signal (Incon - Con) | Standard Error 0.43 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Frontial_Sup2 (stroop) | -0.24 BOLD signal (Incon - Con) | Standard Error 0.54 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Cerebelum_Crus2 (stroop) | -0.29 BOLD signal (Incon - Con) | Standard Error 0.91 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Parietal_Inf (MSIT) | 0.50 BOLD signal (Incon - Con) | Standard Error 0.4 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Parietal_Inf (MSIT) | 0.49 BOLD signal (Incon - Con) | Standard Error 0.43 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Angular (MSIT) | 0.35 BOLD signal (Incon - Con) | Standard Error 0.31 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Supp_Motor_Area (MSIT) | 0.49 BOLD signal (Incon - Con) | Standard Error 0.45 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Frontal_Inf_Oper (MSIT) | 0.54 BOLD signal (Incon - Con) | Standard Error 0.52 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Calcarine (MSIT) | 0.45 BOLD signal (Incon - Con) | Standard Error 0.48 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Frontal_Inf_Oper (MSIT) | 0.49 BOLD signal (Incon - Con) | Standard Error 0.53 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Insula (MSIT) | 0.49 BOLD signal (Incon - Con) | Standard Error 0.54 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Frontal_Mid (MSIT) | 0.31 BOLD signal (Incon - Con) | Standard Error 0.37 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Thalamus (MSIT) | 0.32 BOLD signal (Incon - Con) | Standard Error 0.39 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Frontal_Mid_Orb (MSIT) | 0.25 BOLD signal (Incon - Con) | Standard Error 0.53 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Cingulum_Mid2 (MSIT) | -0.40 BOLD signal (Incon - Con) | Standard Error 0.41 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Angular2 (MSIT) | -0.51 BOLD signal (Incon - Con) | Standard Error 0.62 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Frontal_Sup2 (MSIT) | -0.43 BOLD signal (Incon - Con) | Standard Error 0.52 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Frontal_Med_Orb2 (MSIT) | -1.06 BOLD signal (Incon - Con) | Standard Error 1.33 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Hippocampus2 (MSIT) | -0.24 BOLD signal (Incon - Con) | Standard Error 0.37 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Angular2 (MSIT) | -0.27 BOLD signal (Incon - Con) | Standard Error 0.46 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Insula2 (MSIT) | -0.21 BOLD signal (Incon - Con) | Standard Error 0.35 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Temporal_Mid2 (MSIT) | -0.32 BOLD signal (Incon - Con) | Standard Error 0.63 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Cerebellum_Crus2 (MSIT) | -0.42 BOLD signal (Incon - Con) | Standard Error 0.83 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | R Precentral2 (MSIT) | -0.10 BOLD signal (Incon - Con) | Standard Error 0.3 |
| Acute Psychological Stress Task | Neural Activity Measured by fMRI | L Cerebellum_Crus2 (MSIT) | -0.26 BOLD signal (Incon - Con) | Standard Error 0.88 |
Primary
Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline)
Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline).
Time frame: 18 minutes (approximately 9 minutes for each task)
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Acute Psychological Stress Task | Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline) | Stroop task | 0.265 mL/(kg·min) | Standard Deviation 0.452 |
| Acute Psychological Stress Task | Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline) | MSIT task | 0.287 mL/(kg·min) | Standard Deviation 0.431 |