Surgical Procedure, Unspecified
Conditions
Brief summary
This study to compare the impacts of remimazolam or propofol on the left ventricular global longitudinal strain (LV-GLS) during anesthesia induction for non-cardiac surgery. LV-GLS is analyzed by using speckle tracking technique of transthoracic echocardiography.
Detailed description
This study to compare the impacts of remimazolam or propofol on the left ventricular global longitudinal strain (LV-GLS) during anesthesia induction for non-cardiac surgery (n=40). Remimazolam or propofol is randomly administered for anesthesia induction (Group-R and Group-P, respectively) The changes of LV-GLS are analyzed by using using speckle tracking technique. For this study, 2-dimensional of transthoracic echocardiography LV images (apical 2-chamber, 3-chamber, and 4-chamber views) are recorded and stored before administration of remimazolam/propofol (T0), 2 minutes after the administration (T2), 4 minutes after the administration (T4), and 6 minutes after the administration (T6). After the completion of the study, LV-GLS values at T0, T2, T4 and T6 are determined by the off-line analyses of the recorded and stored 2D-images. For the off-line determination of LV-GLS, an automated software of speckle-tracking technique (Qapp Autostrain-LV™, Philips) is employed. The primary measure: Inter-group comparison of the lowest LV-GLS value out of LV-GLS values at T2, T4, and T6. The secondary measures: Inter-group comparisons of the LV-GLS values at T0, T2, T4 and T8. Intra-group comparisons of the LV-GLS value at T0 vs. those at T2, T4 and T8
Interventions
DRUGRemimazolam infusion
Remimazolam infusion for anesthesia induction
Propofol infusion for anesthesia induction
Sponsors
Konkuk University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* left ventricular ejection fraction\> 50% * no left ventricular regional wall motion abnormality
Exclusion criteria
* atrial fibrillation * unfavorable airway * hypotension requiring inotropic support
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the averaged longitudinal strain of the left ventricle (%) | 2.5 minutes | inter-group comparisons of the lowest values of the longitudinal strains of the left ventricle in the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the longitudinal strain of the left ventricle in apical long-axis view (%) | 2.5 minutes | inter-group comparisons of the longitudinal strains of the left ventricle in apical long-xis view of the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction |
| the longitudinal strain of the left ventricle in apical 2 chamber view (%) | 2.5 minutes | inter-group comparisons of the longitudinal strains of the left ventricle in apical 2 chamber view of the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction |
| the longitudinal strain of the left ventricle in apical 4 chamber view (%) | 2.5 minutes | inter-group comparisons of the longitudinal strains of the left ventricle in apical 4 chamber view of the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction |
| the election fraction of the left ventricle | 2.5 minutes | inter-group comparisons of the ejection fraction of the left ventricle in the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction |
Countries
South Korea
Contacts
Primary ContactTae-Yop Kim, MD, PhD
Backup ContactSoi Lee
Outcome results
None listed