Central Venous Pressure, Congestion, Doppler Echocardiography, Heart Failure, Right Heart Catheterisation
Conditions
Keywords
Congestion, Doppler echocardiography, Central venous pressure, Right heart catheterisation, Heart Failure
Brief summary
This study evaluates the accuracy of a comprehensive venous Doppler echography including the portal vein pulsatility index (PVPI) to quantify invasively measured right-sided venous pressures. A substudy will correlate invasive and non-invasive hemodynamic measurements to ballistocardiography and seismocardiography with the Kino-cardiograph (Kino) device (HeartKinetics, Waterloo, Belgium).
Interventions
DIAGNOSTIC_TESTComprehensive transthoracic echocardiography, Doppler echography & Kino-cardiograph (Kino)
As per inclusion criteria, all patients undergo right heart catheterisation to obtain a full profile of invasive hemodynamic measurements, including pulmonary arterial wedge pressure (PAWP), pulmonary artery pressure, right ventricular pressure, right atrial pressure (RAP), superior and/or inferior vena cava pressure, hepatic vein pressure with/without balloon occlusion. Immediately after the invasive hemodynamic exam, a comprehensive 2D, Color Doppler and Doppler echocardiography exam, including a Doppler study of the Vv. hepaticae, V. portae and V. renalis is performed. Based upon logistic feasibility, ballistocardiography and seismocardiography with the completely non-invasive Kino device (HeartKinetics, Waterloo, Belgium) is performed in a subpopulation of patients envisioned to be at least 50 patients.
Sponsors
HeartKinetics
Vrije Universiteit Brussel
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* At least 18 year old and able to provide informed consent; * Consecutive patients scheduled for right heart catheterisation by a dedicated heart failure specialist at the Centre of Cardiovascular Diseases (University Hospital Brussels, Jette, Belgium).
Exclusion criteria
* Major anatomical variations of the portal veins (agenesis of left and right portal vein) and/or arterio-portal vein fistula; * Patients with Child-Pugh B or C liver cirrhosis or liver transplant; * Body Mass Index \< 20 kg/m².
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Portal Vein Pulsatility Index (PVPI) | Crosssectional study without longitudinal follow-up, measurement is obtained during Doppler echography exam | PVPI = (Vmax - Vmin)/Vmax on the portal vein Pulsed wave Doppler signal |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inferior vena cava diameter | Crosssectional study without longitudinal follow-up, measurement is obtained during Doppler echography exam | Inferior vena cava diameter \[mm\] upon end-expiration |
| Inferior vena cava diameter respiratory variation | Crosssectional study without longitudinal follow-up, measurement is obtained during Doppler echography exam | Inferior vena cava diameter respiratory variation \[%\] |
| Hepatic vein Pulsed wave Doppler signal | Crosssectional study without longitudinal follow-up, measurement is obtained during Doppler echography exam | Categorical classification: * Systolic wave \> Diastolic wave * Diastolic wave \> Systolic wave * Systolic flow reversal |
| Time integral of kinetic energy during the cardiac cycle | Crosssectional study without longitudinal follow-up, measurement is obtained during Doppler echography exam | Measured by a combination of ballistocardiography and seismocardiography with the Kino device (HeartKinetics, Waterloo, Belgium). |
| Right ventricular (RV) free wall strain | Crosssectional study without longitudinal follow-up, measurement is obtained during Doppler echography exam | Right ventricular (RV) free wall strain assessed in the RV focused view offline with EchoPAC (General Electric Healthcare, Chicago, IL, United States). |
| Right atrial strain | Crosssectional study without longitudinal follow-up, measurement is obtained during Doppler echography exam | Right atrial strain assessed in the RV focused view offline with EchoPAC (General Electric Healthcare, Chicago, IL, United States). |
| Renal vein Pulsed wave Doppler signal | Crosssectional study without longitudinal follow-up, measurement is obtained during Doppler echography exam | Categorical classification: * Monophasic flow * Discontinuous biphasic flow * Discontinuous monophasic flow |
Countries
Belgium
Outcome results
None listed