Ferroptosis, Intestinal Mucosal Barrier, Sepsis
Conditions
Brief summary
The investigators aim to evaluate the roles of IL-9/E-cadheirin and ferroptosis in the intestinal mucosal barrier injury of sepsis. The results of this study would lay the foundation for revealing the mechanisms of EEN improving immune imbalance of sepsis and provide a new idea to the early treatment of sepsis.
Interventions
PROCEDUREStandard treatments for sepsis
Standard treatments for others
Sponsors
Nanjing First Hospital, Nanjing Medical University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Clinical diagnosis of sepsis 2. Within 3 days of sepsis onset before ICU admission 3. No artificial nutrition (enteral or parenteral nutrition) were provided before ICU admission
Exclusion criteria
1. Ileus 2. Digestive tract hemorrhage 3. Inflammatory bowel disease 4. Cancer or chronic organ dysfunction (e.g., hepatic or renal dysfunction) 5. Malnutrition or immunodeficiency 6. Long-term use of hormones
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of intestinal barrier injury incidence of intestinal barrier injury | 7 days | intestinal barrier injury |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of ferroptosis | 7 days | ferroptosis |
Countries
China
Contacts
Primary ContactJie Zhou, Dr.
Outcome results
None listed