Functional MRI, Prognosis, Rehabilitation; Tobacco Use, Stroke, Upper Extremity Dysfunction
Conditions
Brief summary
30% - 66% of stroke survivors have upper limb dysfunction. Effective rehabilitation can improve the prognosis, but the rehabilitation resources are limited. How to evaluate the prognosis early and formulate an individualized rehabilitation plan based on realistic expectations is still inconclusive. The current research shows that some brain network changes are related to the recovery of motor function. The dynamic connection of multi-modal and spatio-temporal fusion of motor network is helpful to the prognosis analysis of upper limb dyskinesia after stroke. 178 stroke patients will be included in this project. Fugl-Meyer motor function scale (upper limb part) and Action Research Arm Test (ARAT) will be evaluated at enrollment, 1month/3month/6month after onset. According to the results, the groups with good prognosis and poor prognosis will be distinguished; blood oxygen level dependent imaging and diffusion tensor imaging will be collected at the same time to compare the similarities and differences of the function and structural connection of the motion network; the correlation between interhemispheric connection, intrahemispheric connection, cross network connection of motor network and prognosis will be analyzed, the clinical and imaging features of different prognosis will be extracted. This study can provide scientific data support for the prognosis analysis of upper limb dysfunction after stroke, the improvement of rehabilitation clinical decision-making and the optimization of rehabilitation resource allocation.
Interventions
OTHERno intervention
observational research
Sponsors
Fu Xing Hospital, Capital Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* First stroke with upper limb motor dysfunction, Stable condition; 18 ≤age≤80 years old; The onset time was less than 3 weeks at the time of enrollment; Sign informed consent.
Exclusion criteria
* Stroke patients with intracranial infection, multi-system atrophy and other central nervous system diseases; Combined with severe aphasia, visual spatial neglect and other cognitive impairment; Untreated spasm (Ashworth ≥ grade 2); Obvious joint contracture restricting the movement of upper limb; In vivo metal implants; Claustrophobia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Motor assessment at early subacute phase | 1 month after onset | Fugl-Meyer Assessment for Upper Limb |
| Motor assessment at subacute phase | 3 months after onset | Fugl-Meyer Assessment for Upper Limb |
| Motor assessment at chronic phase | 6 months after onset | Fugl-Meyer Assessment for Upper Limb |
| Functional assessment at early subacute phase | 1 month after onset | Action Research Arm Test |
| Functional assessment at subacute phase | 3 months after onset | Action Research Arm Test |
| Functional assessment at chronic phase | 6 months after onset | Action Research Arm Test |
| The motion network of early subacute phase with functional MRI | 1 month after onset | The structural and functional connection of the motion network |
| The motion network of subacute phase with functional MRI | 3 months after onset | The structural and functional connection of the motion network |
| The motion network of chronic phase with functional MRI | 6 months after onset | The structural and functional connection of the motion network |
| Correlation analysis between changes of motor function and changes of motor network | 1 month after onset, 3 months after onset, 6 months after onset | The correlation between interhemispheric connection, intrahemispheric connection, cross network connection of motor network and motor function prognosis will be analyzed |
Contacts
Primary ContactRan Li
Backup ContactYong Wang
Outcome results
None listed