The Effect of General and Spinal Anesthesia on Neutrophil-to-lymphocyte Ratio

Comparison of the Effect of General and Spinal Anesthesia on Umbilical Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio and Mean Platelet Volume in Patients Undergoing Cesarean Section

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05409885

Enrollment

Registered

2022-06-08

Start date

2022-03-20

Completion date

2022-07-07

Last updated

2022-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, General, Anesthesia, Spinal, Umbilical Cord

Keywords

anesthesia, cesarean section, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean platelet volume

Brief summary

The aim of the study was to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients undergoing cesarean section.

Detailed description

This study was designed to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord NLR, PLR and MPV in patients undergoing cesarean section. The primary endpoint was to compare the effects of general and spinal anesthesia on umbilical cord NLR. Secondary endpoints were determined the general and spinal anesthesia on routine umbilical cord PLR, MPV and newborn Apgar scores at 1st and 5th min.

Interventions

OTHERGeneral anesthesia

Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

OTHERSpinal anesthesia

Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* 18 - 45 years * American Society of Anesthesiology (ASA) II-III * elective ceserean surgery

Exclusion criteria

* declining to give written informed consent * under 18 years of age or over 45 years of age * factors affecting NLR, PLR and MPV such as preeclampsia, HELLP syndrome or premature rupture of membranes * history of neurological and/or neuromucular disease * cooperation cannot be established * emergency surgery

Design outcomes

Primary

Measure	Time frame	Description
neutrophil-to-lymphocyte ratio	within 5 minute, following delivery	Evaluate the effects of NLR in patients undergoing cesarean section

Secondary

Measure	Time frame	Description
platelet-to-lymphocyte ratio	within 5 minute, following delivery	Evaluate the effects of PLR in patients undergoing cesarean section
mean platelet volume	within 5 minute, following delivery	Evaluate the effects of MPV in patients undergoing cesarean section
Newborn Apgar score 1st minute	1st minute after birth	Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition)
Newborn Apgar score 5th minute	5th minute after birth	Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition)

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026