Subclinical Hypothyrodism and Ovarian Reserve

Evaluation of Ovarian Reserve in Women With Subclinical Hypothyrodism in Reproductive Age

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05409729

Enrollment

300

Registered

2022-06-08

Start date

2016-01-01

Completion date

2023-08-01

Last updated

2022-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility Disorders

Brief summary

This study aimed to evaluate the potential association of subclinical hypothyrodism and ovarian reserve in reproductive age in age groups more than 35 and age groups less than 35 using retrospective study included women with subclinical hypothyrodism and controls .Evaluation of potential association of antithyroid antibodies positivity on ovarian reserve Primary outcome: Measure the association of SCH with ovarian reserve markers (basal FSH ,LH/basal AFC /AMH)

Detailed description

Thyroid dysfunction is one of the commonest disorders in women of reproductive age .there is association between subclinical hypothyrodism and infertility and ovarian reserve .It's known that subclinical hypothyrodism can be associated with reduced ovarian reserve in women more than 35 years old .Aclear association between subclinical hypothyrodism and ovarian reserve not established in reproductive age in women less than 35 .This retrospective study investigate serum thyroid hormone /Antithyroid hormone ,ovarian reserve markers (basal FSH,AMH,Antral follicle count on day 2-4/prolactin level .

Interventions

BEHAVIORALretrospective charts reviewing

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

13 Years to 45 Years

Inclusion criteria

* All reproductive age groups included women less than 35 and women more than 35

Exclusion criteria

* Previous ovarian surgery Women with long term thyroid hormone replacement Endometriosis History of radiotheraby

Design outcomes

Primary

Measure	Time frame	Description
Measure the association of SCH with ovarian reserve markers (basal FSH ,LH/basal AFC /AMH)	48 months	This study aimed to evaluate the potential association of subclinical hypothyrodism and ovarian reserve in reproductive age in age groups more than 35 and age groups less than 35 using retrospective study included women with subclinical hypothyrodism and controls .Evaluation of potential association of antithyroid antibodies positivity on ovarian reserve

Countries

Egypt

Contacts

Primary ContactEman Ahmed Abed Eltawaab, MBBCH

emanedahmed49@gmail.com01065933793

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026