Idiopathic Granulomatous Mastitis
Conditions
Keywords
Idiopathic granulomatous mastitis, recurrence, albumin-to-globulin ratio, risk factors
Brief summary
Albumin-to-globulin ratio (AGR) is an inflammation-based index that has been shown to have a role in many cancers and inflammatory diseases. Idiopathic granulomatous mastitis (IGM) is a rare inflammatory disease of the breast with a high recurrence rate. As a relatively new biomarker for inflammatory diseases, AGR's role in IGM recurrence has never been investigated in the literature. This study primarily investigates the possible risk factors for IGM recurrence and whether AGR can be used as a predictive factor.
Detailed description
Patients diagnosed with IGM on pathology reports between January 2016 and March 2021 were enrolled in the study and their medical records were analyzed retrospectively. The patients were divided into two groups: recurrence and non-recurrence. Clinical, demographic characteristics, and laboratory parameters were compared. The best cut-off value for significant factors in predicting recurrence was determined by receiver operating characteristic (ROC) analysis. Univariate and multivariate logistic regression analysis was used to determine the risk factors that are effective in IGM recurrence.
Interventions
PROCEDUREsegmental mastectomy
The preferred method in the treatment of some patients diagnosed with IGM
Sponsors
Samsun Education and Research Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The patients with a pathologically confirmed diagnosis of granulomatous mastitis * Patients over the age of 18 * Female patients
Exclusion criteria
* Male patients * Secondary granulomatous mastitis etiologies (tuberculous mastitis and Wegener's granulomatosis) * Patients who do not have enough follow-up information * Patients with missing data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| IGM recurrence | within an average of 3-4 years of follow-up after treatment | Recurrence was defined as the reappearance of breast complaints such as pain, mass, abscess, and fistula at the end of at least three months following remission with treatment. IGM developed in the other breast after the treatment was also accepted as a recurrent case. |
Countries
Turkey (Türkiye)
Outcome results
None listed