Bariatric Surgery Candidate, Healthy, Obese
Conditions
Brief summary
This study is trying to determine whether the success of bariatric surgery can be predicted by evaluating the dietary sugar absorptive characteristics in the small intestine and if there is any gene expression change on the dietary sugar absorptive characteristics.
Interventions
PROCEDUREEndoscopic biopsy
Upper small intestinal biopsies from patients undergoing BS will be collected during routine standard of care screening EGD and again from the same patients at 1 year during routine standard of care surveillance EGD (esophageal reflux screening/surveillance). Biopsy-derived enteroid cultures and tissue samples from pre- and one-year post BS will be examined for expression level of sugar transporters and gluconeogenic enzymes; glucose and fructose absorption
Sponsors
Mayo Clinic
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
\- Obese patients (BMI ≥ 30) scheduled for BS undergoing standard of care screening EGD, or lean BS-naïve individuals (BMI ≤ 25) subjected to EGD for routine clinical indications as part of standard care.
Exclusion criteria
* Adults unable to consent, including non-English speakers. * Pregnant women because endoscopy is a risk factor. All patients of childbearing age undergo history as well as urine pregnancy test as a standard of care prior to undergoing endoscopy as the procedure is performed under anesthesia. * Prisoners. * Subjects with preexisting conditions (e.g., bleeding at the time of the procedure, suspected perforation during the standard-of-care procedure) will be excluded from the study at the time of the endoscopy. * Have a contraindication to endoscopy. * A history of surgery on the stomach or small intestine. * Type 1 diabetes (clinical diagnosis and/or positive glutamic acid decarboxylase antibodies). * Using weight loss medications. * Active malignancy within the last 5 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of obese patients with altered dietary sugar hyper-absorptive phenotype after bariatric surgery | 18 months |
Secondary
| Measure | Time frame |
|---|---|
| Epigenetic changes measured in the intestinal mucosa of obese patients with dietary sugar hyper-absorptive phenotype after bariatric surgery | 18 months |
Countries
United States
Outcome results
None listed