Aortic Aneurysm, Thoracic, Aortic Diseases, Aortic Dissection, Coarctation of Aorta, Hematoma; Aorta
Conditions
Keywords
Antibiotic prophylaxis, TEVAR, Fever, MAGIC classification
Brief summary
The infection rate of thoracic endovascular aortic repair (TEVAR) is unknown due to a lack of epidemiological data. The rate currently available comes from researches conducted decades ago, when open surgery was the standard of care. Because of the potentially fatal consequences of a stent graft infection in the thoracic aorta, the investigators tend to prescribe antibiotic prophylaxis for at least three days. In this study, the investigators are going to collect data on patients receiving TEVAR in the past five years and provide the following information: a. the infection rate (MAGIC classification), b. the rate of fever, c. the results of the lab tests, such as the WBC count and C-reaction protein. d. risk factors associated with infection and fever.
Interventions
PROCEDUREthoracic endovascular aortic repair
In The TEVAR procedure, we implant a stent graft into the diseased area of the thoracic artery, providing a route for the blood to flow within the stent graft and excluding the diseased aorta.
Sponsors
First Affiliated Hospital of Zhejiang University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. Diagnosed with thoracic aortic diseases 2. Received TEVAR
Exclusion criteria
1. Suspected infectious aortic disease, such as a mycotic aneurysm. 2. TEVAR combined with open surgery 3. Antibiotics have been used more than 24 hours before the operation 4. Combined with immune deficiency disease or using hormone or immunosuppressant； 5. The treatment is for the complications of TEVAR, such as endoleak 6. Endovascular aortic repair for abdominal aortic disease 7. History of open aortic surgery or heart surgery. 8. Revascularization of visceral arteries during the TEVAR
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Infection rate after TEVAR | during hospitalization (up to post-operation day 14) | Infection rate via MAGIC classification |
| Infection rate at one month after TEVAR | One month after TEVAR | Infection rate via MAGIC classification |
| Infection rate at six months after TEVAR | Six months after TEVAR | Infection rate via MAGIC classification |
| Infection rate at one year after TEVAR | One year after TEVAR | Infection rate via MAGIC classification |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| WBC count | one day, two days, three days after TEVAR | — |
| C-reaction protein | one day after TEVAR | — |
| Fever | one day, two days, three days, one month, six months, one year after TEVAR | Defined as temperature ≥38.5℃ |
Countries
China
Outcome results
None listed