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AGC Mode vs Minimal Flow in Breast Surgery

Comparison of AGC (Automatic Gas Control) Mode and Manually Controlled Minimal Flow Anesthesia in Breast Surgery

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05404269
Enrollment
90
Registered
2022-06-03
Start date
2021-03-15
Completion date
2022-04-04
Last updated
2022-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia; Functional, Automatic End-tidal Controlled Anesthesia, Breast Diseases, Volatil Agent Consumption

Keywords

anesthesia machine, sevoflurane, minimal fresh gas flow, breast surgery, AGC mode

Brief summary

The aim of this study was to compare the AGC mode and manually controlled minimal-flow anesthesia for volatile anesthetic consumption, hemodynamic parameters, and recovery from anesthesia

Detailed description

Modern anesthesia machines use circular systems in which ventilated gas re-circulates to a certain degree and is therefore reused, preserving temperature, and humidity. The rebreathing fraction is increased by a reduction in fresh gas flow, which leads to a considerable decrease in consumption of fresh gas and volatile anesthetics, resulting in reductions in cost and atmospheric pollution. In a closed ventilation system, only the patient's requirements for oxygen and anesthetic agents are supplemented. A fresh gas flow-rate of 0.5 l/min is defined as the minimal-flow technique. The oxygen and anesthetic gas titration can be manually controlled by the anesthetist. To assure safe and appropriate anesthesia, manually controlled anesthesia requires constant monitoring and numerous adjustments to the gas dosage by the anesthetist, especially for low- and minimalflow anesthesia. Oxygen flow and volatile anesthetics can also be automatically controlled by anesthesia machines using end-tidal control (such as AGC mode of Maquet FLOW-i anesthesia machine), which ensures constant end-tidal concentration of oxygen and anesthetic gas via feedback and continuous automatic adjustment mechanisms. Anesthesiologists needing to make fewer interventions during a case may have clinical importance in terms of distraction, record keeping and patient safety. In addition to this advantage, we wanted to compare the AGC mode and manually controlled minimal-flow anesthesia for volatile anesthetic consumption, hemodynamic parameters, and recovery from anesthesia.

Interventions

DEVICEAGC mode

Automated Gas Control mode at Maquet FLOW-i anesthesia machine

Sponsors

Zonguldak Bulent Ecevit University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* 18-65 years * undergoing breast surgery * ASA physical status I-II * female * operation lasting at least 1 hour * those who agreed to volunteer for the study with an informed consent form

Exclusion criteria

* coronary artery disease, CHF * pregnancy or breastfeeding women * decompensated diabetes mellitus * kidney or liver failure * chronic obstructive pulmonary disease * opioid sensitivity * history of malignant hyperthermia * history of smoking * alcohol or drug addiction * significant anemia * sepsis * BMI \>35 * patients with allergies to the drugs used in the study

Design outcomes

Primary

MeasureTime frameDescription
Consumption of Volatile Agentduring the surgeryDifference of Sevoflurane Consumption between the groups

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026