Perihilar Cholangiocarcinoma
Conditions
Keywords
laparoscopic, minimally invasive, open resection
Brief summary
Brief Summary: This is a multicentric, retrospective, real-world study to investigate the surgical outcomes of minimally invasive surgery compared with open surgery for Perihilar Cholangiocarcinoma (PHC), with the perioperative characteristics and long-term overall survival being compared. We aimed to find out whether the minimally invasive surgery is safe or feasible for PHC. And we also want to find out patients with what kind of characteristic can be benefit from the minimally invasive surgery compared with the open approach.
Interventions
OTHERNo intervention
This is an observational study without any intervention.
Sponsors
Renyi Qin
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
Histologically confirmed PHC.
Exclusion criteria
1. Peritoneal seeding or metastasis to the liver, para-aortic lymph nodes, or distant sites; 2. Non-adenocarcinoma histology; 3. Incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative length of stay | up to 90 days | defined as the time from being admitted to hospital to discharge |
| Overall survival | through study completion, an average of 5 year | defined as the duration from the first day after surgery to either the date of death or the last follow-up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative complications | up to 90 days | Postoperative complications were reviewed within 90 days after surgery and graded according to Clavien-Dindo (CD) classification system.Postoperative biliary leakage, hemorrhage, and liver failure were defined and classified according to the criteria set out by the International Study Group of Liver Surgery (ISGLS). Wound infection was defined as purulent drainage from the incision or/and positive findings of culture of the fluid or tissue aseptically obtained from the incision. |
| Reoperation within 90 days | up to 90 days | defined as any reoperation within 90 days |
| Mortality | up to 90 days | defined as any death within 30 days and 90 days, respectively |
| Vessel reconstruction | intraoperative | defined as any repair or replacement of major vessels during surgery |
| Operative details | intraoperative | including blood transfusion, vascular resection, number of resected lymph nodes |
| R0 resection | intraoperative | defined as tumor-free margins in all the reported surgical margins (biliary and circumferential margins) |
| Intraoperative blood loss | intraoperative | recorded by the anesthetist using a vacuum system |
| Readmission within 90 days | up to 90 days | defined as any readmission within 90 days |
| Operation time | intraoperative | defined as the time from skin incision or trocar placement to complete skin closure |
Countries
China
Outcome results
None listed