Serum Copeptin in Cirrhotic Patients With Spontaneous Bacterial Peritonitis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05401721

Enrollment

Registered

2022-06-02

Start date

2021-05-01

Completion date

2021-12-01

Last updated

2022-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spontaneous Bacterial Peritonitis

Brief summary

Current reports have demonstrated that copeptin predicts disease progression and prognosis in cirrhotic patients, independent of liver-specific scoring systems. To the best of our knowledge, few studies have addressed the association between copeptin and sepsis in cirrhotic patients, however, they were performed on different types of infections. Therefore, we will conduct this study with a focus on it is possible role in patients with SBP.

Interventions

DIAGNOSTIC_TESTSerum copeptin

Blood test

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* The diagnosis of liver cirrhosis will be based on clinical data and findings on abdominal ultrasound. The diagnosis of SBP will be based on the presence of at least 250 cells/ml PMNLs in the ascitic fluid, with or without positive ascitic fluid culture in the absence of hemorrhagic ascites and secondary peritonitis

Exclusion criteria

* Patients with heart failure, coronary insufficiency, advanced chronic respiratory disease, polyuria-polydipsia syndrome and hypotension or shock. * Patients with chronic kidney disease treated with hemodialysis before admission. * Patients with previous liver or kidney transplantation. * Patients with intraabdominal malignancy. * Patients with severe infection other than SBP. * Patients who had received antibiotics before hospital admission.

Design outcomes

Primary

Measure	Time frame	Description
compare serum levels of copeptin in cirrhotic patients with and without SBP	6 months	compare serum levels of copeptin in cirrhotic patients with and without SBP

Secondary

Measure	Time frame	Description
assess serum copeptin levels in different stages of cirrhosis and its relationship with kidney and circulatory function	6 months	assess serum copeptin levels in different stages of cirrhosis and its relationship with kidney and circulatory function

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026