Psoriasis
Conditions
Brief summary
To evaluate effect of acitretin versus Narrowband UVB on serum level of neopterin in psoriatic patients.
Interventions
DRUGAcitretin 25Mg Cap
Acitretin is an oral retinoid (a derivative of vitamin A) given in a dose 0.25-1 mg /kg/day for 3months in psoriatic patients
RADIATIONNarrowband ultraviolet B
Narrowband UVB is the most common form of phototherapy used to treat psoriasis, given 2-3 sessions per week for 3 successive months
Sponsors
South Valley University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
15 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients with psoriasis diagnosed clinically Aged (15-60).
Exclusion criteria
* Patient with history of skin cancer. * Patient with history of photosensitivity. * Pregnancy and lactation. * Liver failure. * Renal failure. * Patient with psoriatic artheritis. * Patient with allergy to product or any of its components. * Patient with poorly controlled dyslipidemia. * Patient receiving tetracyclines.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum Neopterin in psoriasis | 3 Months | Measurement of Neopterin in psoriatic patients before and after treatment with NB-UVB, Acitretin and combination of both modalities using ELISA (enzyme-linked immunosorbent assay). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Treatment of psoriasis | 3 Months | Clinical evaluation: Assessment of disease severity will be performed by using psoriasis area severity index (PASI score) before and after treatment with NB-UVB, Acitretin and combination of both modalities. |
Countries
Egypt
Outcome results
None listed