On-pump Valve Surgery or CABG
Conditions
Brief summary
Although systemic inflammatory response induced by cardiopulmonary bypass is believed as one of main reasons for these adverse events, the involved mechanism is still unclear.This cohort study would include patients undergoing on-pump valve surgery or CABG. By detecting the changes of immune cell expression profile and inflammatory related substances in blood, the spatiotemporal change curve of immune function of patients is drawn for avoiding or treating adverse events.
Interventions
PROCEDUREOn-pump valve surgery or CABG
On-pump valve surgery or coronary arterial bypass grafting
Sponsors
West China Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* (1) participants aged over 18 years; (2) Participants who scheduled for valve replacement or valvuloplasty, coronary artery bypass under CPB.
Exclusion criteria
* (1) participant with a cognitive or mental disorder who is unable to sign an informed consent form; (2) suffering from basic immune system and blood system diseases; (3) pregnancy; (4) preoperative radiotherapy and chemotherapy; (5) receive immunosuppressive drugs within six months;(6) Expected survival time less than 2 years;(7) participated in other intervention clinical trials within 30 days before operation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| composite outcome | From the beginning of surgery to 30 days after surgery or to discharge from hospital | the incidence of vital organ injury, which is defined as a composite measure, including postoperative death, vital organ dysfunction, and mechanical ventilation duration greater than 24 hours. And the vital organ dysfunction includes new kidney injury, long-term low cardiac output, severe liver function injury and neurological function injury. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Infection | From the beginning of surgery to 30 days after surgery or to discharge from hospital] | — |
| MACCE | From the beginning of surgery to 30 days after surgery or to discharge from hospital] | including all-cause mortality, myocardial infarction, severe arrhythmias and stroke |
| Acute lung injury | From the beginning of surgery to 30 days after surgery or to discharge from hospital] | Acute onset of bilateral infiltrates on the chest readiograph and hypoxaema(PaO2/Fi O2 ratio \<300) in the absence of clincial evidence of left atrial hypertension |
| Gastrointestinal complications | From the beginning of surgery to 30 days after surgery or to discharge from hospital | including gastrointestinal bleeding and intestinal ischemia |
Countries
China
Contacts
Primary ContactJing Lin, doctor
Backup ContactTingting Wang, doctor
Outcome results
None listed