AAA - Abdominal Aortic Aneurysm
Conditions
Brief summary
A retrospective cohort study of computed tomography scans of AAA patients considered for repair, in order to identify sex specific differences in abdominal aortic aneurysm (AAA) metrics and the association between anatomical differences/features of complexity and adverse patient outcome.
Detailed description
A retrospective cohort study of computed tomography scans of AAA patients considered for repair. The study aims to, firstly, identify sex specific differences in abdominal aortic aneurysm (AAA) metrics utilising manual and automated image processing techniques; and secondly, if numbers are sufficient, explore the association between features of AAA complexity and adverse patient outcome.
Interventions
DIAGNOSTIC_TESTCTA Aorta
Computed Tomography Angiography - Aorta Whole
Sponsors
Imperial College London
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All adult patients with AAA receiving assessment +/- primary open or endovascular repair at participating centre from 1/1/2010 to 31/12/2020. * Must have AAA \>= 5cm. * Must have CT imaging within 1 year of operation or definitive turn down for treatment.
Exclusion criteria
* Insufficient CT imaging quality (\>3mm slices) or lack of CT within 1 year of operation. * Insufficient clinical data to establish risk factors or clinical outcomes. * Ruptured aneurysm, aorto-iliac occlusive disease, isolated iliac aneurysm, penetrating aortic ulcer, dissection, juxta or supra-renal aneurysm. * Secondary repair/not primary treatment decision for AAA repair.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sex-specific differences in thrombus burden | Pre-operative CT | Volumetric assessment of aortic thrombus |
| Sex-specific differences in anatomical complexity | Pre-operative CT | Anatomical as assessed by current IFU (instructions for use) criteria. (Anatomy within pre-specified vessel diameter, length, tortuosity and calcification criteria for insertion of endovascular stent graft for AAA repair.) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between anatomical differences and adverse patient outcome for patients receiving operative repair - need for transfusion, risk of vessel injury, ischaemia (bowel or limb), renal injury and re-intervention/endoleak. | 30 days | Post-operative outcomes |
Countries
United Kingdom
Outcome results
None listed