Platelet Transfusion Refractoriness
Conditions
Brief summary
Platelet Transfusion Refractoriness is one of the severe complications after multiple transfusions in patients with severe thrombopenia. Platelet Transfusion Refractoriness is characterized by inefficient transfusion and arise from allo-antibodies specific of platelets antigenes, mostly carried by HLA-I molecules.
Detailed description
A preliminary study has shown different isotypes of anti-HLA I in patients with Platelet Transfusion Refractoriness. Our hypothesis is that the type of anti-HLA I antibodies (recognised epitope, quantity, isotype) should establish predictive and diagnostic criteria for Platelet Transfusion Refractoriness.
Interventions
PROCEDUREplatelet transfusion
platelet transfusion realised for Hematopoietic stem cells graft or for acute leukemia
Sponsors
Institut de cancérologie Strasbourg Europe
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patient with Hematopoietic stem cells graft (autograft or allograft) or with acute leukemia with the indication of platelet transfusion.
Exclusion criteria
* Patient under guardianship * Minor patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Research of predictive criteria of Platelet transfusion refractoriness | blood samples before the transfusion of each chemotherapy cycle | Characterisation of anti-HLA I antibodies (recognised epitopes and isotypes) associated to Platelet transfusion refractoriness |
Countries
France
Outcome results
None listed