Rectal Cancer
Conditions
Brief summary
This is a retrospective analysis of all patients diagnosed with LARC who received NCRT and had MRI scans between 2003-2014 at East Suffolk and North Essex NHS Foundation Trust. Region of interest was drawn around the tumor or its location on T2 MRI images. Six texture parameters were systematically extracted from Textural histograms of post-treatment scans. These parameters were examined to determine their ability to predict local recurrence and distant metastases through Kaplan-Meier survival curves and log-rank tests.
Interventions
DIAGNOSTIC_TESTMRI
Texture analysis (TA) is a novel imaging biomarker that can assess heterogeneity in MRIs by measuring grey-level intensities distribution. This study hypothesizes that TA of MRI is an imaging biomarker that can predict local recurrence and distant metastasis.
Sponsors
East Suffolk and North Essex NHS Foundation Trust
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* All subjects must have MRI post-Chemotherapy treatment to detect the response to Neoadjuvant treatment and compare it to pre-treatment scans to easily determine if there were a posttreatment liver metastasis. * Locally advanced rectal cancer (LARC) = MRI stage: T3/T4 and/or N1/N0.
Exclusion criteria
* Distant metastases. * Synchronous tumour.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local recurrence of rectal cancer | 120 months |
Countries
United Kingdom
Outcome results
None listed