DNA Fragmentation - Effect on Pregnancy Rate

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05397314

Enrollment

Registered

2022-05-31

Start date

2016-01-01

Completion date

2021-04-09

Last updated

2022-05-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility, Male

Brief summary

The purpose of this study is to determine whether Punalpin, an antioxidant, has a positive impact on DNA fragmentation in spermatozoa in male fertility patients with increased amount of DNA fragmentation in their spermatozoa. Secondary purpose is to investigate whether there is any positive effect on the subsequent pregnancy rates from the fertility treatment.

Interventions

DIETARY_SUPPLEMENTPunalpin

OTHERPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Male fertility patients with increased amount of DNA fragmentation in their spermatozoa

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Sperm DNA fragmentation	4 months	Reduction in DNA fragmentation

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026