Periodontal Diseases, Saliva Altered, Stroke
Conditions
Brief summary
Methods: 100 consecutive patients with their first ever ischemic stroke were enrolled in the study. 56 randomly selected patients were subjected to stimulation of salivation, the remaining patients were not stimulated. The severity of the neurological condition was assessed using the NIHSS scale on days 1, 3 and 7 of stroke. The incidence of periodontal diseases was classified using the Hall's scale in the 1st day of stroke. On days 1 and 7 of stroke, the concentration of IL-1beta, MMP8, OPG and RANKL in the patients' saliva was assessed using the Elisa technique. At the same time, the level of CRP and the number of leukocytes in the peripheral blood were tested on days 1, 3 and 7 of the stroke, and the incidence of upper respiratory and urinary tract infections was assessed.
Detailed description
The course of an ischemic stroke varies by many factors. The influence of periodontal diseases and the stimulation of salivation on the course and difficulty of stroke remains unresolved. Methods: 100 consecutive patients with their first ever ischemic stroke were enrolled in the study. 56 randomly selected patients were subjected to stimulation of salivation, the remaining patients were not stimulated. The severity of the neurological condition was assessed using the NIHSS scale on days 1, 3 and 7 of stroke. The incidence of periodontal diseases was classified using the Hall's scale in the 1st day of stroke. On days 1 and 7 of stroke, the concentration of IL-1beta, MMP8, OPG and RANKL in the patients' saliva was assessed using the Elisa technique. At the same time, the level of CRP and the number of leukocytes in the peripheral blood were tested on days 1, 3 and 7 of the stroke, and the incidence of upper respiratory and urinary tract infections was assessed.
Interventions
DIAGNOSTIC_TESTsaliva stimulation
In 50 patients with ischemic stroke, saliva was the option of a neurologopedic massage of choice
Sponsors
Pomeranian Medical University Szczecin
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
48 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* men and women, * at the age of 48-80, * first-ever stroke, * with symptoms from the anterior cerebral vascularity (basin of the internal carotid artery), * with a significant neurological deficit (minimum 3 points according to the NIH scale) * capable of giving informed consent;
Exclusion criteria
* aphasia, disturbance of consciousness, mental disorders - making it impossible to express informed consent * surgery of the salivary glands - disrupting the secretion of saliva * diseases of the salivary glands that disrupt the secretion of saliva (diabetes, Sjögren's syndrome, state after radiotherapy in the area of the salivary glands)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| evaluation of saliva parameters od day 1 | day 1 of stroke | On the first day of admission, saliva (2 ml) is collected and the parameters are MMP8 (ng/mL), OPG ( (ng/mL) and RANKL (ng/mL) |
| assessment of blood parameters from day 1 | day 1 of stroke | Assessment of CRP(mg/L) in blood on the first day of hospitalization |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| evaluation of saliva parameters- second measurement | day 7 of stroke | On the seventh day of admission, saliva (2 ml) is collected with the parameters MMP8MMP8 (ng/mL), OPG ( (ng/mL) and RANKL (ng/mL) |
| assessment of blood parameters from day 7 | day 7 of stroke | Assessment of CRP(mg/L) in blood on the seven day of hospitalization |
Other
| Measure | Time frame | Description |
|---|---|---|
| Neurological assessment using the NIHSS scale | day 1 of stroke | On admission, the patient's neurological status is assessed using the NIHSS scale |
Countries
Poland
Outcome results
None listed